Horie Shigeo
Dept. of Urology, Juntendo University, Graduate School of Medicine.
Gan To Kagaku Ryoho. 2017 Mar;44(3):191-195.
Drug-induced nephron-toxicity hampers the effective cancer chemotherapy and impairs the quality of life of the patients. Now eGFR has substituted Ccr for the estimation of renal function. The concepts and clinical significance of CKD and AKI have been established. These progress of clinical nephrology can improve the management of cancer chemotherapy. Clinical practice guidelines for the management of kidney disease in cancer survivors supports health-related professional to practice based on the evidence, which will enhance the efficacy of the treatment and QOL of the cancer survivors.
药物性肾毒性阻碍了有效的癌症化疗，并损害了患者的生活质量。如今，估算肾小球滤过率（eGFR）已取代内生肌酐清除率（Ccr）用于评估肾功能。慢性肾脏病（CKD）和急性肾损伤（AKI）的概念及临床意义已确立。临床肾脏病学的这些进展可改善癌症化疗的管理。癌症幸存者肾脏疾病管理的临床实践指南支持医疗专业人员循证实践，这将提高癌症幸存者的治疗效果和生活质量。
