加纳霉素A和B，两种源自海洋的加纳链霉菌TXC6-16产生的新型γ-丁内酯。
Ghanamycins A and B, two novel γ-butyrolactones from marine-derived streptomyces ghanaensis TXC6-16.
作者信息
Xu Jia-Hui, Gu Kang-Bo, Zhang Dao-Jing, Li Yuan-Guang, Tian Li
机构信息
State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.
First Institute of Oceanography, State Oceanic Administration, Qingdao, China.
出版信息
J Antibiot (Tokyo). 2017 Jun;70(6):733-736. doi: 10.1038/ja.2017.37. Epub 2017 Mar 15.
Two novel γ-butyrolactones ghanamycins A (1) and B (2) were isolated from the fermentation broth of marine-derived Streptomyces ghanaensis TXC6-16. Their structures were elucidated by spectroscopic analysis. These two novel compounds exhibited antimicrobial activities against some phytopathogens. The minimum IC (MIC) of 2 against Pseudomonas syringae and Erwinia sp. were 50 μg ml.
从海洋来源的加纳链霉菌TXC6-16发酵液中分离出两种新型γ-丁内酯——加纳霉素A（1）和B（2）。通过光谱分析阐明了它们的结构。这两种新型化合物对一些植物病原体具有抗菌活性。化合物2对丁香假单胞菌和欧文氏菌属的最小抑菌浓度（MIC）为50μg/ml。
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