Wang Tang, Jiang Yi, Ma Kai-Xia, Li Yi-Qing, Huang Rong, Xie Xiao-Song, Wu Shao-Hua
Key Laboratory for Microbial Resources of the Ministry of Education, Yunnan Institute of Microbiology, Yunnan University, Kunming 650091, P. R. China (phone: +86-871-65032423).
Chem Biodivers. 2014 Jun;11(6):929-33. doi: 10.1002/cbdv.201300321.
Two new butenolides, (4S)-4,10-dihydroxydodec-2-en-1,4-olide (1) and (4S)-4,8,10-trihydroxy-10-methyldodec-2-en-1,4-olide (2), together with three known compounds, MKN-003B (3), MKN-003C (4), and cyclo(Ala-Leu) (5), were isolated from the culture broth of a bacterium of the genus Streptomyces derived from soil environment. The structures of these compounds were elucidated on the basis of spectroscopic analysis. The inhibitory activities of the butenolides against eight pathogenic fungi were evaluated. All of the butenolides showed moderate-or-weak antifungal activities in a broth microdilution assay.
从土壤环境中分离得到的链霉菌属细菌的培养液中，分离出两种新的丁烯内酯，即(4S)-4,10-二羟基十二碳-2-烯-1,4-内酯（1）和(4S)-4,8,10-三羟基-10-甲基十二碳-2-烯-1,4-内酯（2），以及三种已知化合物，MKN-003B（3）、MKN-003C（4）和环（丙氨酸-亮氨酸）（5）。通过光谱分析确定了这些化合物的结构。评估了丁烯内酯对八种致病真菌的抑制活性。在肉汤微量稀释试验中，所有丁烯内酯均表现出中等或较弱的抗真菌活性。
