坎贝斯在三硝基苯磺酸结肠炎模型中的抗炎肠道活性。
Anti-inflammatory intestinal activity of Cambess. in trinitrobenzene sulfonic acid colitis model.
作者信息
de Morais Lima Gedson Rodrigues, Machado Flavia Danniele Frota, Périco Larissa Lucena, de Faria Felipe Meira, Luiz-Ferreira Anderson, Souza Brito Alba Regina Monteiro, Pellizzon Cláudia Helena, Hiruma-Lima Clélia Akiko, Tavares Josean Fechine, Barbosa Filho José Maria, Batista Leônia Maria
机构信息
Gedson Rodrigues de Morais Lima, Flavia Danniele Frota Machado, Josean Fechine Tavares, José Maria Barbosa Filho, Leônia Maria Batista, Departamento de Ciências Farmacêuticas, Centro de Ciências da Saúde, Laboratório de Farmacologia do Trato Gastrintestinal, Universidade Federal da Paraíba (UFPB), Cidade Universitária, João Pessoa, Paraíba, CEP 58051-970, Brazil.
出版信息
World J Gastroenterol. 2017 Feb 28;23(8):1353-1366. doi: 10.3748/wjg.v23.i8.1353.
AIM
To evaluate the anti-inflammatory intestinal effect of the ethanolic extract (EtOHE) and hexane phase (HexP) obtained from the leaves of ().
METHODS
Inflammatory bowel disease was induced using trinitrobenzenesulfonic acid in acute and relapsed ulcerative colitis in rat models. Damage scores, and biochemical, histological and immunohistochemical parameters were evaluated.
RESULTS
Both -EtOHE and -HexP caused significant reductions in macroscopic lesion scores and ulcerative lesion areas. The vegetable samples inhibited myeloperoxidase increase, as well as pro-inflammatory cytokines TNF-α and IL-1β. Anti-inflammatory cytokine IL-10 also increased in animals treated with the tested plant samples. The anti-inflammatory intestinal effect is related to decreased expression of cyclooxygenase-2, proliferating cell nuclear antigen, and an increase in superoxide dismutase.
CONCLUSION
The data indicate anti-inflammatory intestinal activity. The effects may also involve participation of the antioxidant system and principal cytokines relating to inflammatory bowel disease.
目的
评估从（）叶中获得的乙醇提取物（EtOHE）和己烷相（HexP）的抗炎肠道作用。
方法
在大鼠急性和复发性溃疡性结肠炎模型中，使用三硝基苯磺酸诱导炎症性肠病。评估损伤评分以及生化、组织学和免疫组化参数。
结果
EtOHE和HexP均使宏观病变评分和溃疡性病变面积显著降低。植物样品抑制了髓过氧化物酶的增加以及促炎细胞因子TNF-α和IL-1β。在用受试植物样品处理的动物中，抗炎细胞因子IL-10也有所增加。抗炎肠道作用与环氧合酶-2、增殖细胞核抗原的表达降低以及超氧化物歧化酶的增加有关。
结论
数据表明具有抗炎肠道活性。这些作用可能还涉及抗氧化系统和与炎症性肠病相关的主要细胞因子的参与。
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