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结直肠癌中的错配修复蛋白与微卫星不稳定性（MLH1、MSH2、MSH6和PMS2）：组织病理学与免疫组织化学研究

Mismatch Repair Proteins and Microsatellite Instability in Colorectal Carcinoma (MLH1, MSH2, MSH6 and PMS2): Histopathological and Immunohistochemical Study.

作者信息

Ismael Nour El Hoda S, El Sheikh Samar A, Talaat Suzan M, Salem Eman M

机构信息

Faculty of Medicine, Cairo University, Cairo, Egypt.

Ahmed Maher Teaching Hospital, Cairo, Egypt.

出版信息

Open Access Maced J Med Sci. 2017 Mar 15;5(1):9-13. doi: 10.3889/oamjms.2017.003. Epub 2017 Feb 12.

DOI:10.3889/oamjms.2017.003
PMID:28293308
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5320899/
Abstract

BACKGROUND

Colorectal cancer (CRC) is one of the most common cancers worldwide. Microsatellite instability (MSI) is detected in about 15% of all colorectal cancers. CRC with MSI has particular characteristics such as improved survival rates and better prognosis. They also have a distinct sensitivity to the action of chemotherapy.

AIM

The aim of the study was to detect microsatellite instability in a cohort of colorectal cancer Egyptian patients using the immunohistochemical expression of mismatch repair proteins (MLH1, MSH2, MSH6 and PMS2).

MATERIAL AND METHODS

Cases were divided into Microsatellite stable (MSS), Microsatellite unstable low (MSI-L) and Microsatellite unstable high (MSI-H). This Microsatellite stability status was correlated with different clinicopathological parameters.

RESULTS

There was a statistically significant correlation between the age of cases, tumor site & grade and the microsatellite stability status. There was no statistically significant correlation between the gender of patients, tumor subtype, stage, mucoid change, necrosis, tumor borders, lymphocytic response, lymphovascular emboli and the microsatellite stability status.

CONCLUSION

Testing for MSI should be done for all colorectal cancer patients, especially those younger than 50 years old, right sided and high-grade CRCs.

摘要

背景

结直肠癌（CRC）是全球最常见的癌症之一。在所有结直肠癌中，约15%检测到微卫星不稳定性（MSI）。具有MSI的结直肠癌具有特定特征，如生存率提高和预后较好。它们对化疗作用也有明显的敏感性。

目的

本研究的目的是通过错配修复蛋白（MLH1、MSH2、MSH6和PMS2）的免疫组化表达，检测一组埃及结直肠癌患者的微卫星不稳定性。

材料与方法

病例分为微卫星稳定（MSS）、微卫星低度不稳定（MSI-L）和微卫星高度不稳定（MSI-H）。这种微卫星稳定状态与不同的临床病理参数相关。

结果

病例年龄、肿瘤部位和分级与微卫星稳定状态之间存在统计学显著相关性。患者性别、肿瘤亚型、分期、黏液样改变、坏死、肿瘤边界、淋巴细胞反应、淋巴管栓子与微卫星稳定状态之间无统计学显著相关性。

结论

所有结直肠癌患者，尤其是年龄小于50岁、右侧和高级别结直肠癌患者，均应进行MSI检测。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ad9/5320899/a244cd76bbc9/OAMJMS-5-009-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ad9/5320899/c2e653822edb/OAMJMS-5-009-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ad9/5320899/a244cd76bbc9/OAMJMS-5-009-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ad9/5320899/c2e653822edb/OAMJMS-5-009-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ad9/5320899/a244cd76bbc9/OAMJMS-5-009-g002.jpg

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2
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3
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Sci Rep. 2025 Jan 6;15(1):885. doi: 10.1038/s41598-024-83067-2.
4
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Cureus. 2023 Aug 16;15(8):e43571. doi: 10.7759/cureus.43571. eCollection 2023 Aug.
5
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Am J Transl Res. 2023 Feb 15;15(2):1107-1116. eCollection 2023.
6
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6
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