伊朗北部散发性结直肠癌的微卫星不稳定性与特征的相关性。
The Correlation between Microsatellite Instability and the Features of Sporadic Colorectal Cancer in the North Part of Iran.
机构信息
Cellular and Molecular Research Center, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
出版信息
Gastroenterol Res Pract. 2012;2012:756263. doi: 10.1155/2012/756263. Epub 2012 Nov 19.
Abstract
Background. The aim of this study was to determine the correlation between MSI and sporadic colorectal cancer in Guilan province, North part of Iran. Materials and Methods. A total of 96 patients who underwent resection for sporadic colorectal cancer in Guilan province were studied. No patients had positive family history of cancers. The frequencies of MSI were analyzed by testing the BAT-26 and BAT-25 markers. Results. MSI analysis revealed that 22.9% of the tumors (22 patients) were microsatellite instability positive and 77.1% (74 patients) were microsatellite instability negative. The highest rate of MSI (40.9%) was found in the rectal region. MSI-H status was seen more frequently in distal tumors (P = 0.04, odds ratio = 3.13, 0.96-10.14). Conclusions. Distal tumor location and MSI may associate with special clinicopathological features. It seems that there may be correlation with underlying genetic and immunologic mechanisms.
摘要
背景
本研究旨在确定伊朗北部吉兰省 MSI 与散发性结直肠癌之间的相关性。
材料与方法
共研究了 96 例在吉兰省接受散发性结直肠癌切除术的患者。所有患者均无阳性癌症家族史。通过检测 BAT-26 和 BAT-25 标记物分析 MSI 的频率。
结果
MSI 分析显示，22.9%（22 例）的肿瘤呈微卫星不稳定阳性，77.1%（74 例）呈微卫星不稳定阴性。MSI 的最高发生率（40.9%）见于直肠区域。MSI-H 状态在远端肿瘤中更为常见（P=0.04，优势比=3.13，0.96-10.14）。
结论
远端肿瘤位置和 MSI 可能与特殊的临床病理特征相关。似乎与潜在的遗传和免疫机制有关。
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