肌肉减少症与非酒精性脂肪性肝病：它们之间有关系吗？一项系统综述。
Sarcopenia and non-alcoholic fatty liver disease: Is there a relationship? A systematic review.
作者信息
Tovo Cristiane V, Fernandes Sabrina A, Buss Caroline, de Mattos Angelo A
机构信息
Cristiane V Tovo, Sabrina A Fernandes, Caroline Buss, Angelo A de Mattos, Postgraduate Program at Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, RS 90430-080, Brazil.
出版信息
World J Hepatol. 2017 Feb 28;9(6):326-332. doi: 10.4254/wjh.v9.i6.326.
AIM
To perform a systematic review to evaluate the incidence and prevalence of non-alcoholic fatty liver disease (NAFLD) in adult patients with sarcopenia.
METHODS
Randomized clinical trials, cross-sectional or cohort studies including adult patients (over 18 years) with sarcopenia were selected. The primary outcomes of interest were the prevalence or incidence of NAFLD in sarcopenic patients. In the screening process, 44 full-text articles were included in the review and 41 studies were excluded.
RESULTS
Three cross-sectional studies were included. The authors attempted to perform a systematic review, but due to the differences between the studies, a qualitative synthesis was provided. The diagnosis of NAFLD was made by non-invasive methods (image methods or any surrogate markers) in all three evaluated studies. All the studies suggested that there was an independent association between sarcopenia and NAFLD.
CONCLUSION
Sarcopenia is independently associated with NAFLD and possibly to an advanced fibrosis.
目的
进行一项系统评价，以评估肌肉减少症成年患者中非酒精性脂肪性肝病（NAFLD）的发病率和患病率。
方法
选取包括肌肉减少症成年患者（18岁以上）的随机临床试验、横断面研究或队列研究。感兴趣的主要结局是肌肉减少症患者中NAFLD的患病率或发病率。在筛选过程中，该评价纳入了44篇全文文章，排除了41项研究。
结果
纳入了三项横断面研究。作者试图进行一项系统评价，但由于研究之间存在差异，因此进行了定性综合分析。在所有三项评估研究中，NAFLD均通过非侵入性方法（影像学方法或任何替代标志物）进行诊断。所有研究均表明，肌肉减少症与NAFLD之间存在独立关联。
结论
肌肉减少症与NAFLD独立相关，并且可能与晚期纤维化有关。
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