Medeiros Daniele Gorski, Ferreira Luis Fernando, Lamp Jessica da Silva, Telles da Rosa Luis Henrique
Postgraduate Program in Medicine: Hepatology, Federal University of Health Sciences of Porto Alegre (UFCSPA), Porto Alegre, Rio Grande do Sul, Brazil.
School of Electronics, Electrical Engineering and Computer Sciences, Queens University of Belfast (QUB), Belfast, Northern Ireland, United Kingdom.
Eur J Gastroenterol Hepatol. 2025 Feb 1;37(2):129-136. doi: 10.1097/MEG.0000000000002887. Epub 2024 Nov 19.
Resistance training, as a modality of physical exercise, has been recognized as a fundamental pillar in the treatment of metabolic dysfunction-associated steatotic liver disease (MASLD). Current reviews, however, have not given due priority to the specific effects of this type of training on hepatic and clinical markers in individuals with MASLD. This study aimed to compile the available evidence on the impact of resistance training on hepatic and clinical parameters in individuals diagnosed with MASLD. To this end, a systematic search was conducted in the PubMed, Lilacs, Embase, Cochrane, SciELO, and Pedro databases, as well as a manual search, covering the period from January 2011 to December 2023. Randomized clinical trials that evaluated liver fat, insulin resistance, and liver enzymes in individuals with MASLD who were exclusively subjected to resistance training interventions were selected. This study is registered with International Prospective Register of Systematic Reviews (PROSPERO) (CRD4202236638) and the risk of bias in the eligible studies was assessed using ROB 2. Six studies were included, totaling 232 adult participants. Resistance training resulted in a significant reduction in liver fat ( P < 0.001), liver enzymes ( P < 0.05), and insulin resistance ( P < 0.05) in individuals in the strength training group. Furthermore, greater adherence to resistance training (>90%) was observed compared to aerobic training. It is concluded that resistance training can be an easily accepted and consistent option for adults with MASLD, playing an important role in improving the clinical and hepatic markers of these individuals.
抗阻训练作为一种体育锻炼方式，已被公认为是治疗代谢功能障碍相关脂肪性肝病（MASLD）的一项基本支柱。然而，目前的综述尚未充分重视这类训练对MASLD患者肝脏和临床指标的具体影响。本研究旨在汇总关于抗阻训练对确诊为MASLD的个体肝脏和临床参数影响的现有证据。为此，我们在PubMed、Lilacs、Embase、Cochrane、SciELO和Pedro数据库中进行了系统检索，并进行了手工检索，检索时间范围为2011年1月至2023年12月。我们选择了随机临床试验，这些试验评估了仅接受抗阻训练干预的MASLD患者的肝脏脂肪、胰岛素抵抗和肝酶。本研究已在国际系统评价前瞻性注册库（PROSPERO）（CRD4202236638）注册，并使用ROB 2评估了纳入研究的偏倚风险。共纳入六项研究，总计232名成年参与者。抗阻训练使力量训练组个体的肝脏脂肪（P < 0.001）、肝酶（P < 0.05）和胰岛素抵抗（P < 0.05）显著降低。此外，与有氧运动相比，观察到对抗阻训练的依从性更高（>90%）。结论是，抗阻训练对于患有MASLD的成年人来说可能是一个易于接受且持续有效的选择，在改善这些个体的临床和肝脏指标方面发挥着重要作用。
