Fiorino Sirio, Bacchi-Reggiani Maria Letizia, Leandri Paolo, Loggi Elisabetta, Andreone Pietro
Sirio Fiorino, Paolo Leandri, Unità Operativa di Medicina Interna C, Ospedale Maggiore, AUSL Bologna, 40100 Bologna, Italy.
World J Hepatol. 2017 Feb 28;9(6):333-342. doi: 10.4254/wjh.v9.i6.333.
To assess vitamin E efficacy, defined as its ability to induce hepatitis B e antigen (HBeAg) seroconversion, in children with HBeAg-positive persistent hepatitis.
In July 2016, we extracted articles published in MEDLINE and the Cochrane Library using the following search terms: "chronic hepatitis B", "children", "childhood", "therapy", "treatment", "vitamin E", "tocopherols", "tocotrienols". Only randomized controlled trials (RCTs) published in English language were collected.
Three RCTs met inclusion criteria and were considered in the present meta-analysis. Overall, 23/122 children in the treatment group underwent HBeAg seroconversion 3/74 in the control group (OR = 3.96, 95%CI: 1.18-13.25, = 0.025).
Although our meta-analysis has several limits, including the very small number of available studies and enrolled children with HBeAg positivity-related hepatitis, it suggests that vitamin E use may enhance the probability to induce HBeAg seroconversion in these patients. Further well designed and adequately sized trials are required to confirm or deny these very preliminary results.
评估维生素E在HBeAg阳性持续性肝炎患儿中的疗效，该疗效定义为其诱导乙肝e抗原（HBeAg）血清学转换的能力。
2016年7月，我们使用以下检索词从MEDLINE和考克兰图书馆中提取已发表的文章：“慢性乙型肝炎”“儿童”“童年”“疗法”“治疗”“维生素E”“生育酚”“生育三烯酚”。仅收集以英文发表的随机对照试验（RCT）。
三项RCT符合纳入标准并纳入本荟萃分析。总体而言，治疗组122名儿童中有23名发生HBeAg血清学转换，对照组74名儿童中有3名发生HBeAg血清学转换（OR = 3.96，95%CI：1.18 - 13.25，P = 0.025）。
尽管我们的荟萃分析存在一些局限性，包括可用研究数量极少以及纳入的HBeAg阳性相关肝炎患儿数量有限，但这表明使用维生素E可能会增加这些患者诱导HBeAg血清学转换的概率。需要进一步设计良好且规模适当的试验来证实或否定这些非常初步的结果。
