Heichel Jens, Wilhelm Frank, Kunert Kathleen S, Hammer Thomas
Department of Ophthalmology, University Hospital of Martin Luther, University Halle-Wittenberg, Halle (Saale), Germany.
Augen im Zentrum, Greifswald, Germany.
Med Hypothesis Discov Innov Ophthalmol. 2016 Winter;5(4):125-131.
The porcine eye is often used as an ex vivo animal model in ophthalmological research. It is well suited for investigations concerning refractive surgery; however, corneal topography data are scarce. This study investigated the corneal topography and pachymetry of the porcine eye to provide further reproducible data. We evaluated freshly enucleated porcine eyes (n = 16) by performing computerized corneal topographies (Orbscan® IIz, Bausch and Lomb, Rochester, NY, USA). We assessed the steepest and flattest keratometric powers (K1 and K2, units in diopters (D)), astigmatism (D), white-to-white (WTW) diameter (mm), thinnest point pachymetry (µm), anterior and posterior best-fit sphere (BFS) (D), refractive power of the anterior and posterior curvatures, and total refractive power of the cornea (D). The mean keratometric powers were 39.6 ± 0.89 D (K1) and 38.5 ± 0.92 D (K2), and the mean astigmatism was 1.1 ± 0.78 D. The mean WTW diameter was 13.81 ± 0.83 mm, and the mean corneal thickness was 832.6 ± 40.18 µm. The BFSs were 38.14 ± 0.73 D (anterior) and 42.56 ± 1.15 D (posterior), and the mean refractive powers were 43.27 ± 1.08 D (anterior) and -5.15 ± 0.20 D (posterior); therefore, the mean of the total refractive power was 38.16 ± 1.00 D. The topography and pachymetry of the porcine cornea showed a specific configuration differing from the human cornea. When using animal ex vivo models such as porcine corneas for experimental corneal surgery, findings such as these should be considered.
猪眼常被用作眼科研究中的离体动物模型。它非常适合用于屈光手术相关的研究;然而,角膜地形图数据却很稀少。本研究对猪眼的角膜地形图和角膜厚度进行了调查,以提供更多可重复的数据。我们通过计算机化角膜地形图(美国纽约罗切斯特市博士伦公司的Orbscan® IIz)对16只新鲜摘除的猪眼进行了评估。我们评估了最陡峭和最平坦的角膜曲率计屈光度(K1和K2,单位为屈光度(D))、散光(D)、白到白(WTW)直径(mm)、最薄点角膜厚度(µm)、前和后最佳拟合球面(BFS)(D)、前和后曲率的屈光力以及角膜的总屈光力(D)。平均角膜曲率计屈光度为39.6±0.89 D(K1)和38.5±0.92 D(K2),平均散光为1.1±0.78 D。平均WTW直径为13.81±0.83 mm,平均角膜厚度为832.6±40.18 µm。BFS分别为38.14±0.73 D(前)和42.56±1.15 D(后),平均屈光力分别为43.27±1.08 D(前)和-5.15±0.20 D(后);因此,总屈光力的平均值为38.16±1.00 D。猪眼角膜的地形图和角膜厚度显示出一种与人类角膜不同的特定构型。当使用猪角膜等动物离体模型进行实验性角膜手术时,应考虑到这些发现。