Shahraki Kourosh, Hosseini Seyed-Rafi, Amini Fard Atefeh, Shademan Hashem, Shahraki Kianoush, Salari Amir Masood, Amini Fard Mohammad-Naeim
Department of Ophthalmology, Alzahra Eye Hospital, Zahedan University of Medical Sciences, Zahedan, Iran.
Department of Optometry, School of Rehabilitation, Zahedan University of Medical Sciences, Zahedan, Iran.
Med Hypothesis Discov Innov Ophthalmol. 2016 Winter;5(4):136-144.
We aimed to compare the therapeutic effects of topical 1% sodium hyaluronate (Healon) or hydroxypropyl methylcellulose (HPMC) for the treatment of alkali-induced epithelial corneal defects. An alkali burn was produced in 30 corneas of 30 New Zealand White rabbits, using a 7.5-mm-diameter trephine. The rabbits were randomly divided into three groups. Four times a day, one group was treated with 1% sodium hyaluronate, one with HPMC, and one (the control group) with physiologic saline. During the treatment period, the size of the epithelial defect was observed every day, up to day 17, using a slit-lamp biomicroscope (with fluorescein). Sodium hyaluronate significantly accelerated the wound healing process compared with saline and increased the healing rate to an even greater extent compared with HPMC. Sodium hyaluronate, but not HPMC, is an effective wound-healing adjuvant for alkali-induced corneal epithelial defects.
我们旨在比较局部应用1%透明质酸钠（Healon）或羟丙基甲基纤维素（HPMC）治疗碱烧伤所致角膜上皮缺损的疗效。使用直径7.5毫米的环钻在30只新西兰白兔的30只角膜上造成碱烧伤。将兔子随机分为三组。一组每天4次接受1%透明质酸钠治疗，一组接受HPMC治疗，另一组（对照组）接受生理盐水治疗。在治疗期间，使用裂隙灯生物显微镜（加荧光素）每天观察上皮缺损的大小，直至第17天。与生理盐水相比，透明质酸钠显著加速了伤口愈合过程，与HPMC相比，愈合率提高的程度更大。透明质酸钠而非HPMC是碱烧伤所致角膜上皮缺损的有效伤口愈合辅助剂。
