年轻脑梗死患者血小板花生四烯酸水平较低。

Low platelet arachidonic acid in young patients with brain infarction.

作者信息

Färkkilä M A, Rasi V, Tilvis R S, Ikkala E, Viinikka L, Ylikorkala O, Färkkilä A M, Miettinen T A

机构信息

Second Department of Medicine, University of Helsinki.

出版信息

Thromb Res. 1987 Dec 15;48(6):721-7. doi: 10.1016/0049-3848(87)90437-3.

DOI:10.1016/0049-3848(87)90437-3

PMID:2829382

Abstract

Fatty acid patterns of plasma and platelet lipids, platelet aggregation and thromboxane A2 (TxA2) production were studied in young patients (n = 12) with brain infarction and in healthy controls (n = 13). Platelet arachidonic acid content was significantly reduced in the stroke patients, but in vitro platelet aggregation was similar in the two groups. A low dose of acetosalicylic acid (ASA) (100 mg) suppressed thromboxane production and normalized the platelet arachidonic acid values. The low arachidonic acid in platelets is probably due to its increased consumption, indicating platelet activation in vivo.

摘要

对12例年轻脑梗死患者和13名健康对照者的血浆和血小板脂质的脂肪酸模式、血小板聚集及血栓素A2（TxA2）生成进行了研究。卒中患者的血小板花生四烯酸含量显著降低，但两组的体外血小板聚集情况相似。低剂量乙酰水杨酸（ASA）（100毫克）可抑制血栓素生成并使血小板花生四烯酸值恢复正常。血小板中花生四烯酸含量低可能是由于其消耗增加，表明体内血小板被激活。