铅对红细胞嘧啶5'-核苷酸酶和δ-氨基乙酰丙酸脱水酶抑制作用的比较。

Comparison of inhibition of erythrocyte pyrimidine 5'-nucleotidase and delta-aminolevulinic acid dehydratase by lead.

作者信息

Tomokuni K, Ichiba M

机构信息

Department of Community Health Science, Saga Medical School, Japan.

出版信息

Toxicol Lett. 1988 Feb;40(2):159-63. doi: 10.1016/0378-4274(88)90157-9.

DOI:10.1016/0378-4274(88)90157-9

Abstract

The effect of lead on the activities of erythrocyte pyrimidine 5'-nucleotidase (P5N) and delta-aminolevulinic acid dehydratase (ALAD) was investigated in control and lead-exposed workers. The inhibitory effect of lead in vivo and in vitro was more remarkable on the ALAD than on the P5N activity values. It was demonstrated that the pH optimum of both ALAD and P5N in lead workers shifts to the acidic side (nearly pH 6.0) compared to that in control workers.

摘要

研究了铅对对照组和铅接触工人红细胞嘧啶5'-核苷酸酶（P5N）及δ-氨基乙酰丙酸脱水酶（ALAD）活性的影响。铅在体内和体外对ALAD活性值的抑制作用比对P5N的更显著。结果表明，与对照组工人相比，铅接触工人中ALAD和P5N的最适pH均向酸性侧偏移（接近pH 6.0）。

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