[化学化合物对肾上腺切除动物的细胞遗传学活性]
[Cytogenetic activity of chemical compounds in adrenalectomized animals].
作者信息
Variliak I R, Saglo V I
出版信息
Tsitol Genet. 1987 Sep-Oct;21(5):343-9.
PMID:2829397
Abstract
Pyrimethamine, sodium salicylate or ethanol were administered to adrenalectomized rats 3 and 21 days after the operation. It is shown that cytogenetic effect in the operated rats is less pronounced, particularly 3 weeks after the operation. Adrenaline (0.2 mg/kg) increases the effect of chemicals on the chromosome apparatus, while hydrocortisone (50 mg/kg) and corticotropin (10 U/kg) decrease it.
摘要
在肾上腺切除术后3天和21天，给大鼠施用乙胺嘧啶、水杨酸钠或乙醇。结果表明，手术大鼠的细胞遗传学效应不那么明显，尤其是在术后3周。肾上腺素（0.2毫克/千克）增强了化学物质对染色体装置的作用，而氢化可的松（50毫克/千克）和促肾上腺皮质激素（10单位/千克）则降低了这种作用。
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