Ol'shanetskaia V A, Totskiĭ V N, Andrievskiĭ A N
Probl Endokrinol (Mosk). 1977 Mar-Apr;23(2):103-8.
The effect of adrenalectomy, and also of adrenaline, hydrocortisone and ACTH on the rate of lipoate-35S penetration into the mitochondria of the liver was studied in rats. Bilateral adrenalectomy proved to decrease the rate of the lipoate penetration into the organellae significantly; this was more pronounced in female than in the male rats. The capacity of hepatic mitochondria to absorp the lipoic acid was restored under the effect of single adrenaline, hydrocortisone and ACTH injections. Actinomycin D administered to the animals for a period of 3 days in combination with hydrocortisone eliminated the stimulating effect of the hormone on the lipoate transport into the mitochondria of the liver of the intact and adrenalectomized rats completely. The data obtained pointed to the regulating effect of some hormones on the intensity of penetration of lipoate into the biological structures.
研究了肾上腺切除术以及肾上腺素、氢化可的松和促肾上腺皮质激素对大鼠肝脏线粒体中硫辛酸-35S渗透速率的影响。双侧肾上腺切除术被证明会显著降低硫辛酸渗透到细胞器中的速率；这在雌性大鼠中比在雄性大鼠中更为明显。单次注射肾上腺素、氢化可的松和促肾上腺皮质激素后，肝线粒体吸收硫辛酸的能力得以恢复。在给动物连续3天注射放线菌素D的同时给予氢化可的松，完全消除了该激素对完整大鼠和肾上腺切除大鼠肝脏线粒体中硫辛酸转运的刺激作用。所获得的数据表明某些激素对硫辛酸渗透到生物结构中的强度具有调节作用。
