Department of Liver Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Sci Rep. 2017 Mar 15;7:44652. doi: 10.1038/srep44652.
Hepatocellular carcinoma is the most common liver malignancy. Salvage liver transplantation (SLT) is viewed as a feasible cure for recurrence of HCC after resectomy, but the effect is under dispute. A retrospective study examined data at Renji Hospital for 239 transplants from January 2006 to December 2015, including 211 who received primary liver transplantation (PLT) and 28 who underwent SLT. A multivariable cox regression model was employed to pick out relative factors to overall survival (OS) and recurrence free survival (RFS). Propensity score matching (PSM) was used to balance the bias. Both OS and RFS were worse in SLT group than in PLT group, especially for those patients within Milan criteria. Our study demonstrates that SLT bears higher risk of recurrence and death than PLT, indicating that SLT should be given a more careful thought at performance.
肝细胞癌是最常见的肝脏恶性肿瘤。挽救性肝移植（SLT）被认为是肝切除术后 HCC 复发的可行治疗方法，但效果存在争议。一项回顾性研究检查了仁济医院 2006 年 1 月至 2015 年 12 月的 239 例移植数据，其中 211 例接受了原发性肝移植（PLT），28 例接受了 SLT。采用多变量 Cox 回归模型选择与总生存（OS）和无复发生存（RFS）相关的因素。采用倾向评分匹配（PSM）来平衡偏差。SLT 组的 OS 和 RFS 均劣于 PLT 组，尤其是米兰标准内的患者。我们的研究表明，SLT 比 PLT 具有更高的复发和死亡风险，表明在进行 SLT 时应更加谨慎。
