Sección Virus Oncogénicos, Subdepto. de Enfermedades Virales, Instituto de Salud Pública de Chile, Santiago, Chile.
Dirección de Atención Primaria, Servicio de Salud Metropolitano Central, Santiago, Chile.
J Med Virol. 2017 Sep;89(9):1646-1653. doi: 10.1002/jmv.24805. Epub 2017 Mar 28.
Here, we evaluated the prevalence of Human Papillomavirus (HPV) in two groups of Chilean women. The first group consisted of 3235 women aged 18-64 years attended in six primary care centers of Santiago. The second group consisted of 456 women 18-85 aged who consulted the Gynaecology Department of the Reference Hospital of Santiago. Samples were collected from October 2012 to February 2016. Cervical swabs were analyzed both HPV genotyping by PCR and Reverse Line Blot, and cervical cytology by Pap testing. Results showed a prevalence of 12.0% HPV positive, 10.3% high-risk (HR) HPV types positive, 3.9% low-risk (LR) HPV types positive, and 1.0% Pap positive in group 1. The most frequent types were 16, 66, and 59, with a prevalence of 3.0%, 1.6%, and 1.5%, respectively. The prevalence were 71.9% HPV positive, 67.3% HR-HPV types positive, 13.6% LR-HPV types positive, and 62.5% Pap positive in group 2. The most frequent types were 16, 31, and 58, with prevalence of 33.6%, 10.5%, and 7.0%, respectively. Among infected women with HPV: 7.6% were infected with HPV16 or HPV18, 3.0% with HPV31, HPV33 or HPV45, and 6.7% with any other HR-HPV. These findings show great difference in HPV prevalence and types between primary care and reference center, and provide useful epidemiological information to assess the impact of HPV vaccination in the future.
在这里，我们评估了两组智利女性的人乳头瘤病毒（HPV）流行情况。第一组包括 3235 名年龄在 18-64 岁之间的妇女，她们在圣地亚哥的六个初级保健中心就诊。第二组包括 456 名年龄在 18-85 岁之间的妇女，她们在圣地亚哥参考医院的妇科就诊。样本采集于 2012 年 10 月至 2016 年 2 月。采用 PCR 和反向线印迹法对宫颈拭子进行 HPV 基因分型，并进行巴氏涂片检查宫颈细胞学。结果显示，第 1 组 HPV 阳性率为 12.0%，高危（HR）HPV 型阳性率为 10.3%，低危（LR）HPV 型阳性率为 3.9%，巴氏涂片阳性率为 1.0%。最常见的类型是 16、66 和 59，其流行率分别为 3.0%、1.6%和 1.5%。第 2 组 HPV 阳性率为 71.9%，HR-HPV 型阳性率为 67.3%，LR-HPV 型阳性率为 13.6%，巴氏涂片阳性率为 62.5%。最常见的类型是 16、31 和 58，流行率分别为 33.6%、10.5%和 7.0%。在感染 HPV 的女性中：7.6%感染 HPV16 或 HPV18，3.0%感染 HPV31、HPV33 或 HPV45，6.7%感染任何其他 HR-HPV。这些发现表明初级保健和参考中心之间 HPV 流行率和类型存在很大差异，并提供了有用的流行病学信息，以评估 HPV 疫苗接种在未来的影响。
