利尿剂对兔心肌钾交换、机械功能及动作电位的急性影响。

Acute effects of diuretics on potassium exchange, mechanical function and the action potential in rabbit myocardium.

Poole-Wilson P A, Cobbe S M, Fry C H

Clin Sci Mol Med Suppl. 1978 Dec;55(6):555-9. doi: 10.1042/cs0550555.

Abstract

We have studied the acute effects of frusemide, triamterene and amiloride on potassium exchange, the action potential and mechanical function of isolated rabbit myocardium. 2. Potassium exchange in the myocardium was unaltered by these diuretics. 3. Frusemide and amiloride did not affect the action potential of rabbit papillary muscles. Triamterene caused a transient shortening of the action potential. 4. Frusemide and triamterene did not alter myocardial mechanical function in rabbit papillary muscles or the interventricular septum. Amiloride caused a reduction of about 5% in developed tension in two out of three papillary muscles.

摘要

我们研究了速尿、氨苯蝶啶和阿米洛利对家兔离体心肌钾交换、动作电位及机械功能的急性影响。2. 这些利尿剂未改变心肌中的钾交换。3. 速尿和阿米洛利不影响家兔乳头肌的动作电位。氨苯蝶啶使动作电位短暂缩短。4. 速尿和氨苯蝶啶不改变家兔乳头肌或室间隔的心肌机械功能。阿米洛利使三根乳头肌中的两根的张力发展降低约5%。