[肝硬变时血管调节性内皮功能障碍、心肌功能障碍的超声心动图评估及肺循环血流动力学]
[Disorders of Vasoregulative Endothelial Function, Echocardiographic Assessment of Myocardial Dysfunction and Hemodynamics of Pulmonary Circulation in Cirrhosis of the Liver].
作者信息
Kalacheva T P, Chernyavskaya G M, Beloborodova E I, Rachkovskiy M I, Beloborodova E V, Ostanko V L
机构信息
Siberian State Medical University, Tomsk, Russia.
出版信息
Kardiologiia. 2016 Jan;56(1):41-47. doi: 10.18565/cardio.2016.1.41-47.
AIM
to study relationship between parameters of intracardiac hemodynamics assessed by Doppler echocardiography and functional activity of endothelium, hepatic blood flow and severity of portal hypertension in patients with cirrhosis of the liver (CL) of different etiology.
RESULTS
We found that changes of structural and functional parameters of the heart in LC depended on the stage of compensation of portal hypertension and were accompanied by rearrangement of parameters of intracardiac hemodynamics. Pulmonary arterial hypertension (PAH) was found in 11.1% of patients with LC. PAH was moderate and was more frequent in patients with end-stage disease (Child-Pugh class C) compared with those with initial stage of LC (21.4% and 6.3%, p<0.05, respectively).
CONCLUSION
Disorders of vasoregulating endothelial function in patients with CL were related to parameters of cardiopulmonary hemodynamics and functional state of the right ventricle and were more pronounced in patients with PAH.
目的
研究通过多普勒超声心动图评估的心脏内血流动力学参数与不同病因肝硬化（CL）患者内皮功能活性、肝血流量及门静脉高压严重程度之间的关系。
结果
我们发现，肝硬化患者心脏结构和功能参数的变化取决于门静脉高压的代偿阶段，并伴有心脏内血流动力学参数的重新排列。11.1%的肝硬化患者出现肺动脉高压（PAH）。PAH为中度，与肝硬化初期患者相比，终末期疾病（Child-Pugh C级）患者中PAH更为常见（分别为21.4%和6.3%，p<0.05）。
结论
肝硬化患者血管调节内皮功能障碍与心肺血流动力学参数及右心室功能状态有关，在PAH患者中更为明显。
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