[冠心病患者使用原研和通用型比索洛尔的比较前瞻性临床经济学研究]
[Comparative Prospective Clinical Economic Study of Original and Generic Bisoprolol in Patients With Coronary Heart Disease].
作者信息
Tarlovskaya E I, Chudinovskih T I
机构信息
1Nizhny Novgorod State Medical Academy, Nizhny Novgorod, Russia: 2Kirov State Medical Academy Kirov, Russia.
出版信息
Kardiologiia. 2016 May;56(5):12-17. doi: 10.18565/cardio.2016.5.12-17.
PURPOSE
to conduct comparative clinical and economical analysis of original and generic preparations of bisoprolol.
MATERIALS AND METHODS
The study included 61 patients after acute coronary syndrome (ACS) (34 men, 27 women, age 46-78 years). Patients were distributed (envelope method) to 2 groups. Patients of group A received original bisoprolol, of group C - generic drug. Duration of observation was 6 weeks. Parameters analyzed were dynamics of heart rate (HR), data of treadmill exercise test, and values of calculated cost/effectiveness ratio.
RESULTS
In both groups we observed significant slowing of HR. Data of treadmill test showed similar increases of volume of work.
目的
对比比索洛尔原研制剂和仿制药的临床及经济性。
材料与方法
该研究纳入61例急性冠脉综合征（ACS）患者（34例男性，27例女性，年龄46 - 78岁）。患者通过信封法分为两组。A组患者接受比索洛尔原研制剂，C组患者接受仿制药。观察期为6周。分析的参数包括心率（HR）动态变化、平板运动试验数据以及计算得出的成本效益比数值。
结果
两组患者的心率均显著减慢。平板试验数据显示工作量有相似程度的增加。
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