Cabral Agustina, López Soto Eduardo J, Epelbaum Jacques, Perelló Mario
Laboratory of Neurophysiology, Multidisciplinary Institute of Cell Biology (IMBICE), Universidad de La Plata-Consejo Nacional de Investigaciones Científicas y Técnicas, CONICET, and Comision de Investigaciones de la Provincia de Buenos Aires (CIC), Buenos Aires 1900, Argentina.
Department of Neuroscience, Brown University, Providence, RI 02912, USA.
Int J Mol Sci. 2017 Mar 15;18(3):638. doi: 10.3390/ijms18030638.
Ghrelin is an octanoylated peptide that acts via its specific receptor, the growth hormone secretagogue receptor type 1a (GHSR-1a), and regulates a vast variety of physiological functions. It is well established that ghrelin is predominantly synthesized by a distinct population of endocrine cells located within the gastric oxyntic mucosa. In addition, some studies have reported that ghrelin could also be synthesized in some brain regions, such as the hypothalamus. However, evidences of neuronal production of ghrelin have been inconsistent and, as a consequence, it is still as a matter of debate if ghrelin can be centrally produced. Here, we provide a comprehensive review and discussion of the data supporting, or not, the notion that the mammalian central nervous system can synthetize ghrelin. We conclude that no irrefutable and reproducible evidence exists supporting the notion that ghrelin is synthetized, at physiologically relevant levels, in the central nervous system of adult mammals.
胃饥饿素是一种辛酰化肽，通过其特异性受体1a型生长激素促分泌素受体（GHSR-1a）发挥作用，并调节多种生理功能。众所周知，胃饥饿素主要由位于胃泌酸黏膜的一群独特的内分泌细胞合成。此外，一些研究报告称，胃饥饿素也可在某些脑区合成，如下丘脑。然而，关于胃饥饿素由神经元产生的证据并不一致，因此，胃饥饿素是否能在中枢产生仍存在争议。在此，我们对支持或不支持哺乳动物中枢神经系统能够合成胃饥饿素这一观点的数据进行了全面综述和讨论。我们得出结论，不存在无可辩驳且可重复的证据支持在成年哺乳动物中枢神经系统中，胃饥饿素能在生理相关水平上合成这一观点。
