粒细胞输注在侵袭性真菌感染治疗中的应用
Granulocyte transfusions in the management of invasive fungal infections.
作者信息
West Kamille A, Gea-Banacloche Juan, Stroncek David, Kadri Sameer S
机构信息
Department of Transfusion Medicine, National Institutes of Health Clinical Center, Bethesda, MD, USA.
Experimental Transplantation and Immunology Branch, National Cancer Institute, Bethesda, MD, USA.
出版信息
Br J Haematol. 2017 May;177(3):357-374. doi: 10.1111/bjh.14597. Epub 2017 Mar 14.
Abstract
Granulocyte transfusions have a long history of being used in patients with neutropenia or neutrophil dysfunction to prevent and treat invasive fungal infections. However, there are limited and conflicting data concerning its clinical effectiveness, considerable variations in current granulocyte transfusion practices, and uncertainties about its benefit as an adjunct to modern antifungal therapy. In this review, we provide an overview on granulocyte transfusions and summarize the evidence on their role in the prevention and treatment of invasive fungal infections.
摘要
粒细胞输注用于中性粒细胞减少或中性粒细胞功能障碍患者以预防和治疗侵袭性真菌感染已有很长历史。然而，关于其临床疗效的数据有限且相互矛盾，当前粒细胞输注实践存在很大差异，并且对于其作为现代抗真菌治疗辅助手段的益处也存在不确定性。在本综述中，我们概述了粒细胞输注，并总结了其在预防和治疗侵袭性真菌感染中作用的证据。
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