Pasqualone Gianmario, Buzzatti Elisa, Palmieri Raffaele, Savi Arianna, Pascale Maria Rosaria, Borsellino Beatrice, Guarnera Luca, Buccisano Francesco, Voso Maria Teresa, Maurillo Luca, Sconocchia Giuseppe, Venditti Adriano, Del Principe Maria Ilaria
Hematology, Department of Biomedicine and Prevention, Università degli studi di Roma Tor Vergata, Rome, Italy.
Institute of Translational Pharmacology, Department of Biomedical Sciences, National Research Council (CNR), Rome, Italy.
Front Oncol. 2022 Sep 15;12:970188. doi: 10.3389/fonc.2022.970188. eCollection 2022.
Myeloid sarcoma is a hematologic malignancy consisting of extramedullary tissue involvement by myeloid blasts, usually considered as acute myeloid leukemia and treated accordingly. The disease itself, together with chemotherapy and disease-associated factors, may have an impact in increasing the risk of developing severe and frequently life-threatening infections. Herein, we describe the case of a patient with a right breast skin lesion, histologically diagnosed myeloid sarcoma, who developed a severe disseminated fungal infection by (), during the first consolidation course of chemotherapy. Despite maximum antifungal therapy, the infection progressed and the fungus continued to be isolated until granulocyte transfusion therapy was initiated. Our experience suggests that patients with profound and long-lasting neutropenia could benefit from granulocyte transfusions as additional therapy in severe fungal infections resistant to broad-spectrum antimicrobial therapy.
髓系肉瘤是一种血液系统恶性肿瘤，由髓系母细胞累及髓外组织构成，通常被视为急性髓系白血病并据此进行治疗。该疾病本身，连同化疗及疾病相关因素，可能会增加发生严重且常危及生命的感染的风险。在此，我们描述了一例右乳皮肤病变、经组织学诊断为髓系肉瘤的患者，在化疗的首个巩固疗程期间发生了由（）引起的严重播散性真菌感染。尽管进行了最大程度的抗真菌治疗，感染仍进展，且真菌持续分离出来，直至开始粒细胞输注治疗。我们的经验表明，深度且持久中性粒细胞减少的患者，作为对广谱抗菌治疗耐药的严重真菌感染的附加治疗，可能从粒细胞输注中获益。
