Visser L C, Sloan C Q, Stern J A
Department of Medicine & Epidemiology, School of Veterinary Medicine, University of California, Davis, Davis, CA.
J Vet Intern Med. 2017 May;31(3):668-677. doi: 10.1111/jvim.14688. Epub 2017 Mar 13.
Studies evaluating right ventricular (RV) structural and functional abnormalities in feline hypertrophic cardiomyopathy (HCM) are limited.
Right ventricular structural and functional abnormalities are present in cats with HCM and are associated with clinical severity.
Eighty-one client-owned cats.
Retrospective 2-dimensional (2D) echocardiographic study. Right atrial diameter (RAD), RV free wall thickness (RVFWd), RV internal dimension (RVIDd), RV fractional area change (FAC), and tricuspid annular plane systolic excursion (TAPSE) were measured in control cats (n = 26), cats with subclinical HCM (subclinical HCM; n = 31), and cats with HCM and congestive heart failure (HCM + CHF; n = 24).
Right heart size (RAD, RVFWd, and RVIDd) and RV function (FAC and TAPSE) significantly (all P < .05) increased and decreased, respectively, in the HCM + CHF group compared with controls. In the subclinical HCM group, only RVFWd was significantly (P < .05) higher than in controls. Compared with reference intervals derived from controls, 29% of cats with HCM had increased RVFWd. Increased left ventricular free wall thickness, increased RVIDd and decreased TAPSE independently correlated with increased left atrial size. Cats with HCM and pleural effusion were significantly more likely to have increased RVFWd and had increased RAD and decreased TAPSE compared with cats without pleural effusion.
Right ventricular remodeling and dysfunction occur in some cats with HCM and may be associated with clinical severity. Our results support involvement of RV in the pathophysiology of HCM in some cats and support echocardiographic assessment of the RV in cats with HCM.
评估猫肥厚型心肌病（HCM）右心室（RV）结构和功能异常的研究有限。
HCM猫存在右心室结构和功能异常，且与临床严重程度相关。
81只客户拥有的猫。
回顾性二维（2D）超声心动图研究。测量了对照组猫（n = 26）、亚临床HCM猫（亚临床HCM；n = 31）和HCM合并充血性心力衰竭猫（HCM + CHF；n = 24）的右心房直径（RAD）、右心室游离壁厚度（RVFWd）、右心室内径（RVIDd）、右心室面积变化分数（FAC）和三尖瓣环平面收缩期位移（TAPSE）。
与对照组相比，HCM + CHF组的右心大小（RAD、RVFWd和RVIDd）和右心室功能（FAC和TAPSE）分别显著增加和降低（所有P < .05）。在亚临床HCM组中，仅RVFWd显著高于对照组（P < .05）。与对照组得出的参考区间相比，29%的HCM猫RVFWd增加。左心室游离壁厚度增加、RVIDd增加和TAPSE降低与左心房大小增加独立相关。与无胸腔积液的猫相比，有胸腔积液的HCM猫更有可能出现RVFWd增加，且RAD增加和TAPSE降低。
一些HCM猫出现右心室重构和功能障碍，可能与临床严重程度相关。我们的结果支持在某些猫中右心室参与HCM的病理生理过程，并支持对HCM猫进行右心室的超声心动图评估。
