急性肺栓塞伴胸腔积液时阿替普酶的评估。
Evaluation of AT in acute pulmonary embolism with pleural effusion.
作者信息
Yang Lianbiao, Dong Kexin, Zhang Beibei, Mu Qirui, Xia Yuxin, Bai Tuanli, Cui Zhaoxing, Yang Jin, Kong Hongyuan, Li Zhenkun
机构信息
Department of Respiratory Medicine, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650101, P.R. China.
Department of Medical Oncology, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650101, P.R. China.
出版信息
Biomark Med. 2024;18(23):1017-1026. doi: 10.1080/17520363.2024.2395241. Epub 2024 Nov 27.
We aimed to investigate whether there is a correlation between AT and pleural effusion in PE patients. We retrospectively enrolled 325 patients aged 66.26 ± 14.86 years with acute PE in 256-computed tomography pulmonary angiography (CTPA) from 2015 to 2022 and recorded radiographic, clinical and biomarker data, the patients were divided into two groups, PE with pleural effusion group (178 patients) and PE without pleural effusion group (147 patients), odds ratios (OR) were estimated for AT of pleural effusion in PE. A lower AT had a significantly increased risk of pleural effusion (adjusted OR: 2.009, 95% CI: 1.225-3.295). AT are reduced in PE patients with pleural effusion and are associated with the risk of pleural effusion.
我们旨在研究急性肺栓塞（PE）患者中，活化凝血时间（AT）与胸腔积液之间是否存在相关性。我们回顾性纳入了2015年至2022年期间，年龄为66.26±14.86岁、接受256层计算机断层扫描肺动脉造影（CTPA）检查的325例急性PE患者，并记录影像学、临床和生物标志物数据。将患者分为两组，即伴有胸腔积液的PE组（178例患者）和不伴有胸腔积液的PE组（147例患者），估算PE患者胸腔积液AT的比值比（OR）。较低的AT显著增加胸腔积液风险（校正OR：2.009，95%置信区间：1.225-3.295）。伴有胸腔积液的PE患者AT降低，且与胸腔积液风险相关。
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