Baynes R D, Bezwoda W R, Mansoor N
Department of Hematology and Oncology, University of the Witwatersrand Medical School, Johannesburg, South Africa.
Am J Clin Pathol. 1988 Feb;89(2):225-8. doi: 10.1093/ajcp/89.2.225.
In an attempt to elucidate the previously observed decrease in plasma lactoferrin-neutrophil ratio in subjects with acute viral infections, a study of the neutrophil lactoferrin content in such infections was undertaken. With the use of an immunoperoxidase stain for lactoferrin, neutrophils in viral illness were shown to have reduced lactoferrin content (mean score 97.9 +/- SD [38.0] per 100 neutrophils) as compared with normal subjects (mean score 196.4 +/- SD [3.6] per 100 neutrophils) (t = 7.69; P less than 0.0005). This suggests an acquired defect of neutrophil lactoferrin synthesis in viral infection. This finding is of importance when seen against the well-recognized increased risk of bacterial superinfection in subjects who have recently had a viral infection.
为了阐明先前观察到的急性病毒感染患者血浆乳铁蛋白-中性粒细胞比值降低的原因，对这类感染中中性粒细胞的乳铁蛋白含量进行了一项研究。通过使用针对乳铁蛋白的免疫过氧化物酶染色，发现病毒感染患者的中性粒细胞乳铁蛋白含量（每100个中性粒细胞的平均评分为97.9±标准差[38.0]）低于正常受试者（每100个中性粒细胞的平均评分为196.4±标准差[3.6]）（t = 7.69；P<0.0005）。这表明病毒感染时中性粒细胞乳铁蛋白合成存在后天缺陷。鉴于近期有病毒感染的患者发生细菌重叠感染的风险明显增加，这一发现具有重要意义。
