Kampf Jan, Stülke Jörg
Department of General Microbiology, Georg-August-University Göttingen, Germany.
Environ Microbiol Rep. 2017 Jun;9(3):182-185. doi: 10.1111/1758-2229.12530. Epub 2017 Apr 3.
In order to resist harmful environmental conditions, many bacteria form multicellular aggregates called biofilms. In these biofilms, they protect themselves in a self-produced matrix consisting of extracellular polysaccharides, proteins and DNA. In many bacteria, biofilm formation is stimulated in the presence of the second messenger cyclic di-GMP. In this issue of Environmental Microbiology Reports, Bedrunka and Graumann have studied matrix production by the proteins encoded in the Bacillus subtilis ydaJKLMN operon. For the first time, they were able to provide a link between c-di-GMP signalling and matrix production in this bacterium. The work demonstrates that the c-di-GMP receptor protein YdaK forms a membrane-bound complex with the YdaM and YdaN proteins, and that this interaction with YdaK is required for polysaccharide production by YdaL, YdaM and YdaN.
为了抵御有害的环境条件，许多细菌会形成称为生物膜的多细胞聚集体。在这些生物膜中，它们在由细胞外多糖、蛋白质和DNA组成的自身产生的基质中保护自己。在许多细菌中，第二信使环二鸟苷酸（c-di-GMP）的存在会刺激生物膜的形成。在本期《环境微生物学报告》中，贝德伦卡和格劳曼研究了枯草芽孢杆菌ydaJKLMN操纵子编码的蛋白质产生基质的情况。他们首次能够在这种细菌中建立c-di-GMP信号传导与基质产生之间的联系。这项工作表明，c-di-GMP受体蛋白YdaK与YdaM和YdaN蛋白形成膜结合复合物，并且YdaL、YdaM和YdaN产生多糖需要这种与YdaK的相互作用。
