[红细胞分布宽度及平均血小板体积与子痫前期严重程度的关系]
[Relation of red cell distribution width and mean platelet volume with the severity of preeclampsia].
作者信息
Viana-Rojas Jesús Antonio, Rosas-Cabral Alejandro, Prieto-Macías Jorge, Terrones-Saldívar Ma Carmen, Arcos-Noguez Patricia, Bermúdez-Gómez Julieta, Martínez-Padilla Lidia Estephanie, Sandoval-Valdez Darío Alejandro, Hernández-González Flavio, Serrano-Díaz Leopoldo César
机构信息
Departamento de Medicina, Universidad Autónoma de Aguascalientes, Aguascalientes, Aguascalientes, México.
出版信息
Rev Med Inst Mex Seguro Soc. 2017 Mar-Apr;55(2):176-181.
BACKGROUND
It has been established a strong association between the red cell distribution width (RDW) and mean platelet volume (MPV) with hypertension in non-pregnant patients. However, few studies have been performed in patients with preeclampsia, yielding inconsistent results. Our aim is to evaluate the relationship between RDW and MPV with the severity of preeclampsia.
METHODS
Analytic cross-sectional study. We include 64 patients with preeclampsia (26 mild, 38 severe) and 70 patients with normotensive pregnancy. Clinical data, sociodemographic characteristics and laboratory measures, including RDW and MPV, were recorded for each patient.
RESULTS
Hemoglobin and platelet count measures were similar between groups. Preeclamptic patients had levels of RDW (14.7 ± 1.4 vs. 13.4 ± 0.7, p = 0.0001) and MPV (11.8 ± 2.4 vs. 11.0 ± 1.4, p = 0.03) more elevated than control group. Moreover, severe preeclamptic subgroup had more elevated levels of RDW (15.0 ± 1.6 vs. 14.0 ± 0.6, p = 0.001) and MPV (12.7 ± 2.8 vs. 10.8 ± 1.8, p = 0.01) in comparison with mild preeclamptic patients.
CONCLUSIONS
We demonstrate that RDW and MPV are accessible and inexpensive measures associated with the severity of preeclampsia.
背景
在非妊娠患者中，已证实红细胞分布宽度（RDW）和平均血小板体积（MPV）与高血压之间存在密切关联。然而，针对子痫前期患者的研究较少，结果也不一致。我们的目的是评估RDW和MPV与子痫前期严重程度之间的关系。
方法
分析性横断面研究。我们纳入了64例子痫前期患者（26例轻度，38例重度）和70例血压正常的孕妇。记录每位患者的临床资料、社会人口学特征和实验室指标，包括RDW和MPV。
结果
两组之间的血红蛋白和血小板计数指标相似。子痫前期患者的RDW水平（14.7±1.4 vs. 13.4±0.7，p = 0.0001）和MPV水平（11.8±2.4 vs. 11.0±1.4，p = 0.03）高于对照组。此外，与轻度子痫前期患者相比，重度子痫前期亚组的RDW水平（15.0±1.6 vs. 14.0±0.6，p = 0.001）和MPV水平（12.7±2.8 vs. 10.8±1.8，p = 0.01）更高。
结论
我们证明，RDW和MPV是与子痫前期严重程度相关的易于获得且成本低廉的指标。
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