Jung In Young, Ann Hea Won, Kim Jung Ju, Lee Se Ju, Kim Jinnam, Seong Hye, Oh Dong Hyun, Kim Yong Chan, Kim Eun Jin, Jeong Su Jin, Ku Nam Su, Choi Jun Yong, Song Young Goo, Kim June Myung
Department of Internal Medicine AIDS Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.
Medicine (Baltimore). 2017 Mar;96(11):e6332. doi: 10.1097/MD.0000000000006332.
Kikuchi-Fujimoto disease (KFD) is a rare, self-limiting disorder that typically affects the cervical lymph nodes (LNs). Although initially described in young women, KFD also occurs in men. There are no reports on the clinical manifestations and characteristics of male KFD patients. Therefore, this study was conducted to assess the incidence of KFD among males, as well as the most frequent clinical characteristics of these patients. A retrospective, cross-sectional study was performed at a tertiary hospital of patients pathologically confirmed as having KFD from LN biopsy specimens. Clinical and laboratory data, and treatment outcomes of the enrolled patients, were analyzed by gender. A total of 254 patients diagnosed with KFD were enrolled. There were 189 females and 65 males (2.9:1). The mean age was 32.6 ± 11.3 years. Compared to the female patients, the males had more frequent manifestations of fever (48% vs 67%, P = 0.008), headache (9% vs 20%, P = 0.013), bilateral lymphadenopathy (31% vs 46%, P = 0.029), thrombocytopenia (14% vs 29%, P = 0.014), elevated C-reactive protein (CRP) (35% vs 78.4%, P < 0.001), elevated liver enzymes (15% vs 41%, P < 0.001), and elevated lactate dehydrogenase (LDH) (61% vs 80%, P = 0.021). Male patients had fewer autoimmune features (9% vs 2%, P = 0.043) and fewer positive antinuclear antibodies (32% vs 10%, P = 0.006). In this study, 25.6% of the enrolled patients were male, with a 2.9:1 female-to-male sex ratio. Male patients showed a distinctive profile characterized by a higher frequency of fever, headache, bilateral lymphadenopathy, and thrombocytopenia, as well as elevated liver enzymes, CRP, and LDH.
菊池-藤本病（KFD）是一种罕见的自限性疾病，通常累及颈部淋巴结。尽管最初在年轻女性中被描述，但KFD也发生于男性。目前尚无关于男性KFD患者临床表现和特征的报道。因此，本研究旨在评估男性中KFD的发病率以及这些患者最常见的临床特征。在一家三级医院对经淋巴结活检标本病理确诊为KFD的患者进行了一项回顾性横断面研究。按性别对纳入患者的临床和实验室数据以及治疗结果进行了分析。共纳入254例诊断为KFD的患者。其中女性189例，男性65例（比例为2.9:1）。平均年龄为32.6±11.3岁。与女性患者相比，男性患者发热（48%对67%，P=0.008）、头痛（9%对20%，P=0.013）、双侧淋巴结病（31%对46%，P=0.029）、血小板减少（14%对29%，P=0.014）、C反应蛋白（CRP）升高（35%对78.4%，P<0.001）、肝酶升高（15%对41%，P<0.001）以及乳酸脱氢酶（LDH）升高（61%对80%，P=0.021）的表现更为常见。男性患者的自身免疫特征较少（9%对2%，P=0.043），抗核抗体阳性者也较少（32%对10%，P=0.006）。在本研究中，纳入患者中有25.6%为男性，男女比例为2.9:1。男性患者表现出独特的特征，发热、头痛、双侧淋巴结病和血小板减少的发生率较高，同时肝酶、CRP和LDH也升高。
