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用于治疗插管区狭窄和动静脉移植物静脉吻合术的支架移植物。

Stent grafts for treatment of cannulation zone stenosis and arteriovenous graft venous anastomosis.

作者信息

Shemesh David, Goldin Ilya, Olsha Oded

机构信息

Department of Surgery and Hemodialysis Access Center, Shaare Zedek Medical Center, Jerusalem - Israel.

出版信息

J Vasc Access. 2017 Mar 6;18(Suppl. 1):47-52. doi: 10.5301/jva.5000680. Epub 2017 Mar 5.

Abstract

Stent grafts (SGs) are widely used for treatment of failing vascular accesses, fistulas and grafts. The mechanical barrier of the covered stent prevents in-stent stenosis and can be used to effectively correct ruptured vein and aneurysms. Treatment of cannulation zone stenosis with SG can be justified when its use is obligatory, in order to prevent total access loss. Although there are worrying complications attendant on SG insertion and cannulation, including jeopardizing future access creation, most studies report no complications of SG in cannulation zone stenosis. SGs for treatment of arteriovenous graft venous anastomosis stenosis is controversial. Two large randomized trials conclusively demonstrate improved primary patency with SGs at the venous anastomosis of arteriovenous graft at up to two years when compared with percutaneous transluminal angioplasty, sustained for up to 2 years and reducing the number of interventions per patient year. However, the ultimate goal of SG treatment of venous anastomosis stenosis is preventing thrombosis and increasing graft longevity, which was unfortunately not fully achieved.

摘要

覆膜支架(SGs)广泛应用于治疗功能衰竭的血管通路、动静脉内瘘和人工血管。覆膜支架的机械屏障可防止支架内狭窄,并可用于有效纠正破裂的静脉和动脉瘤。当必须使用SG来防止完全失去血管通路时,用其治疗插管区狭窄是合理的。尽管SG置入和插管存在令人担忧的并发症,包括危及未来血管通路的建立,但大多数研究报告称SG用于插管区狭窄时无并发症。SG用于治疗动静脉人工血管静脉吻合口狭窄存在争议。两项大型随机试验确凿地表明,与经皮腔内血管成形术相比,SG在动静脉人工血管静脉吻合口处的原发性通畅率在长达两年的时间内有所提高,这种改善可持续长达2年,并减少了每年每位患者的干预次数。然而,SG治疗静脉吻合口狭窄的最终目标是预防血栓形成并延长人工血管使用寿命,但遗憾的是这一目标并未完全实现。

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