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经圆孔 CT 引导选择性经皮射频热凝术治疗孤立性上颌神经原发性三叉神经痛。

CT-guided selective percutaneous radiofrequency thermocoagulation via the foramen rotundum for isolated maxillary nerve idiopathic trigeminal neuralgia.

机构信息

Departments of1Pain and.

2Anesthesia, First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi,China.

出版信息

J Neurosurg. 2018 Jan;128(1):211-214. doi: 10.3171/2016.9.JNS152520. Epub 2017 Mar 3.

Abstract

OBJECTIVE Although CT-guided selective percutaneous radiofrequency thermocoagulation (PRFT) via the foramen rotundum (FR) has been used in the clinic as a novel successful treatment for isolated, second division (maxillary nerve [V2]), idiopathic trigeminal neuralgia (ITN), there is only very limited related literature published to date. This report aims to provide more detail for physicians about this technique. METHODS Between March 2013 and April 2014, 20 patients with isolated V2 ITN refractory to or intolerant of drug treatment were treated by CT-guided selective PRFT via the FR at the First Affiliated Hospital of Nanchang University. The outcome of pain relief was assessed using the Barrow Neurological Institute (BNI) pain score, and grouped as good (BNI Class I or II, no medication required) and bad (BNI Class III-V, medication required or failed). Recurrence was defined as a relapse to a previous lower level after attainment of any higher level of pain relief. Adverse effects and complications were also monitored and recorded. RESULTS All patients (100%) obtained good pain relief including BNI Class I in 17 patients (85%) and BNI Class II in 3 patients (15%) immediately postoperatively. None of the patients were lost to follow-up. During the mean follow-up period of 24.3 months (range 18-30 months), 2 patients (10%) experienced recurring pain and the mean time until recurrence was 10.5 months (range 8-13 months). No adverse effects or complications occurred except for transient numbness restricted to the V2 dermatome in all patients (100%) and facial hematoma in 3 patients (15%). CONCLUSIONS In the current study, CT-guided selective PRFT via the FR not only achieved absolute selective lesioning to V2, but also helped patients attain successful pain relief with few adverse effects. These limited data suggest that CT-guided selective PRFT via the FR appears to be a feasible, safe, effective, and even relatively ideal treatment for isolated V2 ITN, but these findings need confirmation from further studies.

摘要

目的 尽管经圆孔(FR)CT 引导选择性经皮射频热凝(PRFT)已被用于临床,作为一种治疗孤立的第二支(上颌神经[V2])、特发性三叉神经痛(ITN)的新方法,但是目前相关文献非常有限。本报告旨在为医生提供更多关于该技术的详细信息。

方法 2013 年 3 月至 2014 年 4 月,南昌大学第一附属医院采用经 FR CT 引导选择性 PRFT 治疗 20 例药物治疗无效或不耐受的孤立 V2 ITN 患者。采用巴罗神经研究所(BNI)疼痛评分评估疼痛缓解效果,并分为良好(BNI Ⅰ级或Ⅱ级,无需药物治疗)和不良(BNI Ⅲ-Ⅴ级,需要药物治疗或失败)。复发定义为在获得任何更高水平的疼痛缓解后,疼痛缓解水平下降至之前的更低水平。还监测和记录了不良反应和并发症。

结果 所有患者(100%)均获得良好的疼痛缓解效果,包括术后即刻 17 例(85%)达到 BNI Ⅰ级和 3 例(15%)达到 BNI Ⅱ级。所有患者均无失访。在平均 24.3 个月(18-30 个月)的随访期间,2 例(10%)患者出现疼痛复发,复发时间平均为 10.5 个月(8-13 个月)。除所有患者(100%)均出现短暂的 V2 皮节感觉麻木和 3 例(15%)出现面部血肿外,无其他不良反应或并发症。

结论 在本研究中,经 FR CT 引导选择性 PRFT 不仅实现了对 V2 的绝对选择性病变,而且帮助患者获得了成功的疼痛缓解,不良反应较少。这些有限的数据表明,经 FR CT 引导选择性 PRFT 似乎是治疗孤立的 V2 ITN 的一种可行、安全、有效的治疗方法,甚至是相对理想的治疗方法,但这些发现需要进一步研究的证实。

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