Severson D L, Carroll R, Kryski A, Ramírez I
Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Calgary, Alberta, Canada.
Biochem J. 1987 Nov 15;248(1):289-92. doi: 10.1042/bj2480289.
Heparin (5 units/ml) produced a rapid (5-10 min) release of lipoprotein lipase (LPL) into the incubation medium of cardiac myocytes. Preincubation of myocytes for 30 min with 0.01-10 microM-isoprenaline, 100 microM-forskolin or 500 microM-8-(4-chlorophenylthio)adenosine 3',5'-cyclic monophosphate did not increase heparin-releasable LPL activity. Incubation with isoprenaline also did not change cellular LPL activity, even though the catecholamine did increase the phosphorylase a activity ratio.
肝素(5单位/毫升)可使脂蛋白脂肪酶(LPL)迅速(5 - 10分钟)释放到心肌细胞的孵育培养基中。将心肌细胞与0.01 - 10微摩尔异丙肾上腺素、100微摩尔福斯高林或500微摩尔8 -(4 - 氯苯硫基)腺苷3',5'-环磷酸预孵育30分钟,并不会增加肝素可释放的LPL活性。与异丙肾上腺素孵育也不会改变细胞LPL活性,尽管该儿茶酚胺确实增加了磷酸化酶a的活性比。