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带状疱疹疫苗在自身免疫性和炎性疾病患者中的长期有效性

Longterm Effectiveness of Herpes Zoster Vaccine among Patients with Autoimmune and Inflammatory Diseases.

作者信息

Yun Huifeng, Xie Fenglong, Baddley John W, Winthrop Kevin, Saag Kenneth G, Curtis Jeffrey R

机构信息

From the University of Alabama at Birmingham, Birmingham, Alabama; Oregon Health and Science University, Portland, Oregon, USA.

H. Yun, PhD, University of Alabama at Birmingham; F. Xie, MS, University of Alabama at Birmingham; J.W. Baddley, MD, MPH, University of Alabama at Birmingham; K. Winthrop, MD, MPH, Oregon Health and Science University; K.G. Saag, MD, MSc, University of Alabama at Birmingham; J.R. Curtis, MD, MS, MPH, University of Alabama at Birmingham.

出版信息

J Rheumatol. 2017 Jul;44(7):1083-1087. doi: 10.3899/jrheum.160685. Epub 2017 Mar 15.

Abstract

OBJECTIVE

The protection duration of herpes zoster (HZ) vaccination is unclear among patients with autoimmune (AI) diseases.

METHODS

Using 2006-2013 Medicare data, HZ vaccinated patients with AI were matched 1:2 to unvaccinated HZ. Incidence rates (IR) and adjusted risk ratios over time were calculated using Poisson regression.

RESULTS

Of 59,627 vaccinated patients, crude IR increased from 0.75/100 person-years during the first year post-vaccination to 1.25 during the seventh year. Vaccinated patients had a significantly lower risk of HZ compared with the unvaccinated through 5 years.

CONCLUSION

HZ vaccination was significantly protective only for about 5 years among patients with AI.

摘要

目的

自身免疫性(AI)疾病患者中带状疱疹(HZ)疫苗的保护持续时间尚不清楚。

方法

利用2006 - 2013年医疗保险数据,将接种HZ疫苗的AI患者与未接种HZ疫苗的患者按1:2进行匹配。使用泊松回归计算随时间变化的发病率(IR)和调整后的风险比。

结果

在59627名接种疫苗的患者中,粗发病率从接种后第一年的0.75/100人年增加到第七年的1.25。在5年时间里,接种疫苗的患者患HZ的风险明显低于未接种疫苗的患者。

结论

HZ疫苗仅在约5年时间内对AI疾病患者具有显著保护作用。

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Long-term persistence of zoster vaccine efficacy.带状疱疹疫苗效力的长期持续性。
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