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静脉注射对乙酰氨基酚与曲马多缓解肾切除术患者全身麻醉后术后疼痛效果的比较研究

Comparative Study of the Effect of Intravenous Paracetamol and Tramadol in Relieving of Postoperative Pain after General Anesthesia in Nephrectomy Patients.

作者信息

Manne Venkata Sesha Sai Krishna, Gondi Srinivasa Rao

机构信息

Department of Anaesthesia, NRI Medical College and Hospital, Guntur, Andhra Pradesh, India.

出版信息

Anesth Essays Res. 2017 Jan-Mar;11(1):117-120. doi: 10.4103/0259-1162.186619.

Abstract

AIM

The aim of this study was to compare the effect of intravenous paracetamol and tramadol in relieving of postoperative pain after general anesthesia for nephrectomy in prospective donor patients for kidney transplantation.

MATERIALS AND METHODS

A randomized study was conducted on 100 adult patients scheduled for nephrectomy aged from 35 to 55 years of both sexes and divided into two groups and were administered intravenous paracetamol and tramadol for postoperative pain relief and assessed with visual analog scale score and variations in vital parameters to assess extent of pain relief.

RESULTS

After statistical interpretation of collected data, the observations were extrapolated. There was a statistically significant difference in the pain intensity scores obtained between the paracetamol and tramadol groups.

CONCLUSION

On the basis of the present study, it is concluded that tramadol due to its lesser onset of action time was superior to paracetamol in providing acute postoperative pain relief.

摘要

目的

本研究旨在比较静脉注射对乙酰氨基酚和曲马多在肾移植供体患者肾切除术后全身麻醉中缓解疼痛的效果。

材料与方法

对100例年龄在35至55岁、计划接受肾切除术的成年患者进行了一项随机研究,这些患者分为两组,分别静脉注射对乙酰氨基酚和曲马多以缓解术后疼痛,并通过视觉模拟量表评分和生命体征参数变化来评估疼痛缓解程度。

结果

对收集的数据进行统计分析后,得出了观察结果。对乙酰氨基酚组和曲马多组的疼痛强度评分存在统计学显著差异。

结论

基于本研究,得出结论:曲马多因其起效时间较短,在提供急性术后疼痛缓解方面优于对乙酰氨基酚。

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本文引用的文献

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Intravenous paracetamol (acetaminophen).静脉注射对乙酰氨基酚(醋氨酚)。
Drugs. 2009;69(1):101-13. doi: 10.2165/00003495-200969010-00007.
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Paracetamol: new vistas of an old drug.对乙酰氨基酚:一种老药的新前景。
CNS Drug Rev. 2006 Fall-Winter;12(3-4):250-75. doi: 10.1111/j.1527-3458.2006.00250.x.
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Mu opioid receptor-dependent and independent components in effects of tramadol.曲马多作用中μ阿片受体依赖性和非依赖性成分
Neuropharmacology. 2006 Sep;51(3):651-8. doi: 10.1016/j.neuropharm.2006.05.008. Epub 2006 Jun 21.
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Pain experienced by laparoscopic donor nephrectomy patients in an academic medical setting.
Prog Transplant. 2003 Jun;13(2):117-22. doi: 10.1177/152692480301300208.
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Laparoscopic or open surgery for living donor nephrectomy.
Nephrol Dial Transplant. 2001 Feb;16(2):383-6. doi: 10.1093/ndt/16.2.383.

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