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静脉注射对乙酰氨基酚与曲马多缓解肾切除术患者全身麻醉后术后疼痛效果的比较研究

Comparative Study of the Effect of Intravenous Paracetamol and Tramadol in Relieving of Postoperative Pain after General Anesthesia in Nephrectomy Patients.

作者信息

Manne Venkata Sesha Sai Krishna, Gondi Srinivasa Rao

机构信息

Department of Anaesthesia, NRI Medical College and Hospital, Guntur, Andhra Pradesh, India.

出版信息

Anesth Essays Res. 2017 Jan-Mar;11(1):117-120. doi: 10.4103/0259-1162.186619.

DOI:10.4103/0259-1162.186619
PMID:28298768
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5341674/
Abstract

AIM

The aim of this study was to compare the effect of intravenous paracetamol and tramadol in relieving of postoperative pain after general anesthesia for nephrectomy in prospective donor patients for kidney transplantation.

MATERIALS AND METHODS

A randomized study was conducted on 100 adult patients scheduled for nephrectomy aged from 35 to 55 years of both sexes and divided into two groups and were administered intravenous paracetamol and tramadol for postoperative pain relief and assessed with visual analog scale score and variations in vital parameters to assess extent of pain relief.

RESULTS

After statistical interpretation of collected data, the observations were extrapolated. There was a statistically significant difference in the pain intensity scores obtained between the paracetamol and tramadol groups.

CONCLUSION

On the basis of the present study, it is concluded that tramadol due to its lesser onset of action time was superior to paracetamol in providing acute postoperative pain relief.

摘要

目的

本研究旨在比较静脉注射对乙酰氨基酚和曲马多在肾移植供体患者肾切除术后全身麻醉中缓解疼痛的效果。

材料与方法

对100例年龄在35至55岁、计划接受肾切除术的成年患者进行了一项随机研究,这些患者分为两组,分别静脉注射对乙酰氨基酚和曲马多以缓解术后疼痛,并通过视觉模拟量表评分和生命体征参数变化来评估疼痛缓解程度。

结果

对收集的数据进行统计分析后,得出了观察结果。对乙酰氨基酚组和曲马多组的疼痛强度评分存在统计学显著差异。

结论

基于本研究,得出结论:曲马多因其起效时间较短,在提供急性术后疼痛缓解方面优于对乙酰氨基酚。

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本文引用的文献

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TRPA1 mediates spinal antinociception induced by acetaminophen and the cannabinoid Δ(9)-tetrahydrocannabiorcol.TRPA1 介导热敏性镇痛药(acetaminophen)和大麻素 Δ(9)-四氢大麻酚(cannabinoid Δ(9)-tetrahydrocannabiorcol)诱导的脊髓镇痛。
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COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression.COX-3,一种受对乙酰氨基酚和其他止痛/退烧药抑制的环氧化酶-1变体:克隆、结构与表达
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Acetaminophen as an adjunct to morphine by patient-controlled analgesia in the management of acute postoperative pain.对乙酰氨基酚作为吗啡的辅助药物用于患者自控镇痛以管理急性术后疼痛。
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