Agarwal Swati, Chaubey Krishna Kumar, Chaubey Abhinav, Agarwal Vikas, Madan Ellora, Agarwal Manvi Chandra
Department of Periodontics, Kothiwal Dental College and Research Centre, Moradabad, Uttar Pradesh, India.
Department of Conservative Dentistry and Endodontics, Kothiwal Dental College and Research Centre, Moradabad, Uttar Pradesh, India.
J Indian Soc Periodontol. 2016 Jul-Aug;20(4):409-416. doi: 10.4103/0972-124X.194270.
Simvastatin (SMV), a new locally delivered drug of class statins, is a specific competitive inhibitor of 3-hydroxy-2-methyl-glutaryl coenzyme A reductase. Statins, besides having lipid-lowering abilities, also have pleiotropic effects like host modulation and bone regeneration. The present study was designed to investigate the effectiveness of SMV, 1.2 mg, in an indigenously prepared biodegradable controlled-release gel as an adjunct to scaling and root planing (SRP).
A total of 60 sites, with pocket depth ≥5 mm, two from each of 30 patients after SRP, were categorized into two treatment groups, for subgingival placement of placebo (Gp 1) or SMV (Gp 2). Clinical parameters were recorded at baseline and at 1, 3 and 6 months comprising plaque index, gingival index, probing pocket depth (PPD) and clinical attachment level (CAL). The osseous changes were evaluated radiographically by measuring vertical gain, INFRA 1 and angle of the defect, INFRA 2 from baseline to 6 months.
All subjects tolerated the drug, without any post-application complication. The treatment improved the periodontal condition in both the groups but significant reductions in PPD (p= 0.04), and INFRA 1 (p= 0.000), along with gain in CAL (p= 0.02) and INFRA 2 (p= 0.000) were observed in Gp 2. In one site, an unexpected 5 mm decrease in INFRA 1 was found.
Local drug delivery of SMV enhanced the beneficial effect of SRP, in pocket reduction, gain in CAL and bone fill.
辛伐他汀（SMV）是一种新型的局部给药他汀类药物，是3-羟基-2-甲基戊二酰辅酶A还原酶的特异性竞争性抑制剂。他汀类药物除了具有降脂能力外，还具有宿主调节和骨再生等多效性作用。本研究旨在探讨1.2毫克辛伐他汀在国产可生物降解控释凝胶中作为龈下刮治和根面平整（SRP）辅助治疗的有效性。
共有60个位点，袋深≥5毫米，来自30例患者，每位患者SRP后有两个位点，分为两个治疗组，分别用于龈下放置安慰剂（第1组）或辛伐他汀（第2组）。在基线、1、3和6个月时记录临床参数，包括菌斑指数、牙龈指数、探诊袋深度（PPD）和临床附着水平（CAL）。通过测量从基线到6个月的垂直增益、INFRA 1和缺损角度、INFRA 2，对骨变化进行影像学评估。
所有受试者均耐受该药物，用药后无任何并发症。两组治疗均改善了牙周状况，但第2组观察到PPD（p = 0.04）和INFRA 1（p = 0.000）显著降低，同时CAL（p = 0.02）和INFRA 2（p = 0.000）增加。在一个位点，发现INFRA 1意外下降了5毫米。
局部给药辛伐他汀增强了SRP在减少牙周袋、增加CAL和骨填充方面的有益效果。
