Bayat M, Garajei A, Afshari Pour E, Hasheminasab M, Ghorbani Y, Kalantar Motamedi M H, Bahrami N
Craniomaxillofacial Research center, Tehran University of Medical Sciences, Tehran, Iran; Oral and Maxillofacial Surgery Department, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
Oral and Maxillofacial Surgery Department, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
Int J Organ Transplant Med. 2017;8(1):43-47. Epub 2017 Feb 1.
Although bone grafts are commonly used in reconstructive surgeries, they are sensitive to local perfusion and are thus prone to severe resorption. Biphosphonates can inactivate osteoclasts and can be used to control the undesirable bone resorption.
To assess the effect of administration of biphosphonates on bone resorption.
20 patients with bony defects who were candidates for free autogenous grafts were randomized into "pamidronate" and "control" groups. Bone segments were soaked in either pamidronate solution or normal saline and were inserted into the area of the surgery. Bone densities were measured post-surgery and in 6-month follow-up. Data were obtained via Digora software and analyzed.
The mean±SD bone density in pamidronate group changed from 93.4±14.6 to 93.6±17.5 (p<0.05); in the control group the density decreased from 89.7±13.2 to 78.9±11.4 (p<0.05). The mean difference of bone density in anterior areas of the jaws showed higher DXA in comparison to posterior regions (p=0.002).
Locally administered pamidronate affects reduction in bone resorption.
尽管骨移植常用于重建手术，但它们对局部灌注敏感，因此容易发生严重吸收。双膦酸盐可使破骨细胞失活，可用于控制不良的骨吸收。
评估双膦酸盐给药对骨吸收的影响。
将20例适合自体游离移植的骨缺损患者随机分为“帕米膦酸盐”组和“对照组”。将骨段浸泡在帕米膦酸盐溶液或生理盐水中，然后植入手术区域。术后及6个月随访时测量骨密度。通过Digora软件获取数据并进行分析。
帕米膦酸盐组的平均±标准差骨密度从93.4±14.6变为93.6±17.5（p<0.05）；对照组的骨密度从89.7±13.2降至78.9±11.4（p<0.05）。颌骨前部区域骨密度的平均差异显示，与后部区域相比，双能X线吸收仪测量值更高（p=0.002）。
局部应用帕米膦酸盐可减少骨吸收。
