Marazziti Donatella
Dipartimento di Medicina Clinica e Sperimentale, Section of Psychiatry, University of Pisa, Via Roma, 67, 56100 Pisa, Italy.
F1000Res. 2017 Feb 23;6:180. doi: 10.12688/f1000research.10094.1. eCollection 2017.
Serotonin (5-HT) continues to attract researchers' interest after almost a century. However, despite these efforts, its role has not yet been fully elucidated. It is now evident that 5-HT does not modulate single functions but rather a multiplicity of activities and behaviors present in both normal and several pathological conditions in a less deterministic way than previously assumed. This article aims to briefly review some of the latest advancements in the general role of 5-HT in psychiatry, particularly in depression, and offer the author's personal reflections.
在近一个世纪后，血清素（5-羟色胺，5-HT）依旧吸引着研究人员的关注。然而，尽管付出了这些努力，其作用尚未得到充分阐明。现在很明显，5-HT并非调节单一功能，而是以一种比先前设想的更不确定的方式调节正常和多种病理状况下的多种活动和行为。本文旨在简要回顾5-HT在精神病学，尤其是抑郁症中的一般作用的一些最新进展，并给出作者个人的思考。
