Frenkel Nicola C, Laclé Miangela M, Borel Rinkes Inne H M, Molenaar Izaak Q, Hagendoorn Jeroen
Department of Surgery, University Medical Center Utrecht, Utrecht, Netherlands.
Department of Pathology, University Medical Center Utrecht, Utrecht, Netherlands.
Case Rep Surg. 2017;2017:6940649. doi: 10.1155/2017/6940649. Epub 2017 Feb 19.
Brunner's gland hamartoma, also called hyperplasia, adenoma, and Brunneroma, is an extremely rare benign proliferative lesion of Brunner's glands in the duodenum. While being mostly small and asymptomatic, they can result in gastrointestinal bleeding and obstruction. We report the case of a 54-year-old man presenting with melena and severe anemia requiring blood transfusion. CT scans showed a large mass of 8 cm in diameter, presumably arising in the duodenum. Endoscopic biopsies were not conclusive. As we were unable to determine the nature of the mass preoperatively and due to the severe symptoms, its size, and the uncertain malignant potential, a classic Whipple procedure was performed. The resected specimen showed extensive proliferation of Brunner's glands without signs of malignancy.
布伦纳腺错构瘤，也称为增生、腺瘤和布伦纳瘤，是十二指肠布伦纳腺极其罕见的良性增生性病变。虽然大多数体积小且无症状，但它们可导致胃肠道出血和梗阻。我们报告了一例54岁男性患者，表现为黑便和严重贫血，需要输血。CT扫描显示一个直径8厘米的大肿块，可能起源于十二指肠。内镜活检结果不明确。由于我们术前无法确定肿块的性质，且鉴于严重症状、肿块大小以及不确定的恶性潜能，遂进行了经典的惠普尔手术。切除标本显示布伦纳腺广泛增生，无恶性迹象。
