Razmjoo Hasan, Peyman Alireza, Rahimi Ali, Modrek Hoda Jafari
Department of Ophthalmology, Isfahan University of Medical Sciences, Isfahan, Iran.
Adv Biomed Res. 2017 Feb 22;6:10. doi: 10.4103/2277-9175.200785. eCollection 2017.
Keratoconus is a progressive degenerative disorder of the cornea in which structural changes in the cornea cause it to become thin and conical in shape. Recently, collagen cross-linking (CXL) has been introduced as an effective intervention in management of progressive keratoconus. Accelerated CXL is a new protocol of this procedure which reduces corneal ultraviolet irradiation exposure time to 5 min. This study aimed to compare visual acuity, keratometry and topographic criteria of keratoconic eyes after conventional and accelerated CXL with a six-month follow-up.
In this prospective interventional study we assessed eyes of 40 patients. Patients were divided into two groups randomly. One group underwent accelerated (5 min) CXL and the other underwent conventional (30 min) CXL. Visual acuity, topographic criteria and keratometry were assessed preoperatively and 6 months postoperatively.
In the present study we assessed 40 patients, 50% of which were right eye (OD) and 50% were left eye (OS). Mean age of patients in the accelerated group was 22.10 and in the conventional group was 22.80 years. Our results showed no significant differences between visual acuity, keratometric and topographic criteria in the two groups before intervention. Likewise our results manifested no significant difference between visual acuity, keratometric, refractive and topographic criteria after intervention.
According to our survey topographic criteria and keratometry improvement in the accelerated and conventional protocol are the same. So accelerated protocol is suggested as a safe and effective option for management of progressive keratoconus.
圆锥角膜是一种角膜进行性退行性疾病，角膜的结构变化导致其变薄并呈圆锥形。最近，胶原交联（CXL）已被引入作为治疗进行性圆锥角膜的有效干预措施。加速胶原交联是该手术的一种新方案，可将角膜紫外线照射时间缩短至5分钟。本研究旨在比较传统胶原交联和加速胶原交联术后圆锥角膜眼的视力、角膜曲率测量和地形图标准，并进行为期6个月的随访。
在这项前瞻性干预研究中，我们评估了40例患者的眼睛。患者被随机分为两组。一组接受加速（5分钟）胶原交联，另一组接受传统（30分钟）胶原交联。术前和术后6个月评估视力、地形图标准和角膜曲率测量。
在本研究中，我们评估了40例患者，其中50%为右眼（OD），50%为左眼（OS）。加速组患者的平均年龄为22.10岁，传统组为22.80岁。我们的结果显示，两组在干预前的视力、角膜曲率测量和地形图标准方面无显著差异。同样，我们的结果表明，干预后两组在视力、角膜曲率测量、屈光和地形图标准方面也无显著差异。
根据我们的研究，加速方案和传统方案在地形图标准和角膜曲率测量改善方面相同。因此，加速方案被认为是治疗进行性圆锥角膜的一种安全有效的选择。
