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颅内硬膜外表皮样囊肿恶变转化为鳞状细胞癌并伴有脑脊液漏

Malignant Transformation of an Intracranial Extradural Epidermoid Cyst into Squamous Cell Carcinoma Presented with Cerebrospinal Fluid Leakage.

作者信息

Seif Bahram, Pourkhalili Reza, Shekarchizadeh Ahmad, Mahzouni Parvin

机构信息

Department of Neurosurgery, Al Zahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.

Department of Pathology, Al Zahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.

出版信息

Adv Biomed Res. 2017 Feb 22;6:16. doi: 10.4103/2277-9175.200791. eCollection 2017.

DOI:10.4103/2277-9175.200791
PMID:28299308
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5343612/
Abstract

We report a case of malignant transformation of an intracranial extradural epidermoid cyst into squamous cell carcinoma (SCC), that presented with cerebrospinal fluid (CSF) leakage at the time of recurrence. Intracranial epidermoid cysts are histologically benign and slow-growing neoplasms. They are congenital lesions that develop from ectodermal remnants during neuroembryogenesis. Malignant transformation of epidermoid cysts into SCC is very rare. Various clinical presentations of these tumors after malignant transformation are mentioned in the literature. None of the previous cases, presented with CSF leakage as the recent case did. In cases of malignant transformation, surgical resection and then adjuvant radiation therapy are highly recommended.

摘要

我们报告一例颅内硬膜外表皮样囊肿恶变成为鳞状细胞癌的病例，该病例在复发时出现脑脊液漏。颅内表皮样囊肿在组织学上是良性且生长缓慢的肿瘤。它们是神经胚胎发育过程中由外胚层残余物形成的先天性病变。表皮样囊肿恶变成为鳞状细胞癌非常罕见。文献中提到了这些肿瘤恶变后的各种临床表现。之前的病例均未像最近这例一样出现脑脊液漏。对于恶变病例，强烈建议手术切除，然后进行辅助放疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49e6/5343612/f61ca35950fc/ABR-6-16-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49e6/5343612/b816425c0975/ABR-6-16-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49e6/5343612/d11ecb541d94/ABR-6-16-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49e6/5343612/724afa30f3ba/ABR-6-16-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49e6/5343612/f61ca35950fc/ABR-6-16-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49e6/5343612/b816425c0975/ABR-6-16-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49e6/5343612/d11ecb541d94/ABR-6-16-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49e6/5343612/724afa30f3ba/ABR-6-16-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/49e6/5343612/f61ca35950fc/ABR-6-16-g004.jpg

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Medicine (Baltimore). 2018 Jan;97(1):e9334. doi: 10.1097/MD.0000000000009334.

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Malignant transformation of an epidermoid cyst in the cerebellopontine angle.桥小脑角表皮样囊肿的恶性转化
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