RUNX蛋白的共价修饰：结构影响功能。

Covalent Modifications of RUNX Proteins: Structure Affects Function.

作者信息

Blumenthal Ezra, Greenblatt Sarah, Huang Guang, Ando Koji, Xu Ye, Nimer Stephen D

机构信息

Sylvester Comprehensive Cancer Center, Miami, FL, 33136, USA.

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

出版信息

Adv Exp Med Biol. 2017;962:33-44. doi: 10.1007/978-981-10-3233-2_3.

DOI:10.1007/978-981-10-3233-2_3

PMID:28299649

Abstract

The RUNX family of transcription factors plays important roles in tissue-specific gene expression. Many of their functions depend on specific post-translational modifications (PTMs), and in this review, we describe how PTMs govern RUNX DNA binding, transcriptional activity, protein stability, cellular localization, and protein-protein interactions. We also report how these processes can be disrupted in disease settings. Finally, we describe how alterations of RUNX1, or the enzymes that catalyze its post-translational modifications, contribute to hematopoietic malignancies.

摘要

转录因子RUNX家族在组织特异性基因表达中发挥着重要作用。它们的许多功能依赖于特定的翻译后修饰（PTM），在本综述中，我们描述了PTM如何调控RUNX与DNA的结合、转录活性、蛋白质稳定性、细胞定位以及蛋白质-蛋白质相互作用。我们还报告了这些过程在疾病状态下是如何被破坏的。最后，我们描述了RUNX1或催化其翻译后修饰的酶的改变如何导致造血系统恶性肿瘤。