Tahirov Tahir H, Bushweller John
Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA, 22908, USA.
Adv Exp Med Biol. 2017;962:21-31. doi: 10.1007/978-981-10-3233-2_2.
The core binding factor (CBF) transcription factor is somewhat unique in that it is composed of a DNA binding RUNX subunit (RUNX1, 2, or 3) and a non-DNA binding CBFβ subunit, which modulates RUNX protein activity by modulating the auto-inhibition of the RUNX subunits. Since the discovery of this fascinating transcription factor more than 20 years ago, there has been a robust effort to characterize the structure as well as the biochemical properties of CBF. More recently, these efforts have also extended to the fusion proteins that arise from the subunits of CBF in leukemia. This chapter highlights the work of numerous labs which has provided a detailed understanding of the structure and function of this transcription factor and its fusion proteins.
核心结合因子（CBF）转录因子在某种程度上是独特的，因为它由一个DNA结合RUNX亚基（RUNX1、2或3）和一个非DNA结合CBFβ亚基组成，CBFβ亚基通过调节RUNX亚基的自抑制来调节RUNX蛋白活性。自从20多年前发现这种迷人的转录因子以来，人们一直在大力努力表征CBF的结构以及生化特性。最近，这些努力也扩展到了白血病中由CBF亚基产生的融合蛋白。本章重点介绍了众多实验室的工作，这些工作使人们对这种转录因子及其融合蛋白的结构和功能有了详细的了解。
