Ebihara Takashi, Seo Wooseok, Taniuchi Ichiro
Howard Hughes Medical Institute, Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO, 63110-1093, USA.
Laboratory for Transcriptional Regulation, RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, 230-0045, Japan.
Adv Exp Med Biol. 2017;962:395-413. doi: 10.1007/978-981-10-3233-2_24.
During hematopoiesis, a variety of cells are generated from stem cells through successive rounds of cell fate determination processes. Studies in the last two decades have demonstrated the involvement of Runx transcription factor family members in differentiation of multiple types of hematopoietic cells. Along with evolutionary conservation, the Runx family is considered to be one of the ancestral regulators of hematopoiesis. It is conceivable that the Runx family is involved in shaping the immune system, which is then comprised of innate and acquired lymphoid cells in vertebrates. In this chapter, we will first summarize roles of Runx proteins during the development of T- and B-lymphocytes, which appeared later during evolution and express antigen specific receptors as a result of DNA recombination processes. We also discuss the recent findings that have unraveled the functions of Runx during differentiation of innate lymphoid cells (ILCs).
在造血过程中，多种细胞通过连续的细胞命运决定过程从干细胞产生。过去二十年的研究表明，Runx转录因子家族成员参与多种造血细胞的分化。除了具有进化保守性外，Runx家族被认为是造血的原始调节因子之一。可以想象，Runx家族参与塑造免疫系统，而脊椎动物的免疫系统由先天性和获得性淋巴细胞组成。在本章中，我们将首先总结Runx蛋白在T淋巴细胞和B淋巴细胞发育过程中的作用，T淋巴细胞和B淋巴细胞在进化过程中出现较晚，并且由于DNA重组过程而表达抗原特异性受体。我们还将讨论最近的研究发现，这些发现揭示了Runx在先天性淋巴细胞（ILC）分化过程中的功能。
