基质金属蛋白酶作为疾病的生物标志物
Matrix Metalloproteases as Biomarkers of Disease.
作者信息
Fonseca Fernando Luiz Affonso, da Costa Aguiar Alves Beatriz, Azzalis Ligia Ajaime, Belardo Thaís Moura Gáscon
机构信息
Departamento de Ciências Biológicas, Instituto de Ciências Químicas, Ambientais e Farmacêuticas, Universidade Federal de São Paulo, Diadema, SP, Brazil.
Laboratório de Análises Clínicas-Anexo 3, Faculdade de Medicina do ABC, Vila Principe de Gales, n.821, Santo André, SP, 09060-650, Brazil.
出版信息
Methods Mol Biol. 2017;1579:299-311. doi: 10.1007/978-1-4939-6863-3_17.
Matrix metalloprotease play a vital role in many cellular processes. Dysfunction in activity of these enzymes has been implicated in the pathogenesis of a number of diseases. Factors that affect the balanced interaction between MMPs and their inhibitors, such as genetic mutations of extracellular matrix components or dysregulation of MMP expression, can lead to various diseases. Due to their essential role in ECM remodeling, MMPs have become targets of interest as biomarkers for the diagnosis and prognosis of diseases associated with alterations of the ECM.
基质金属蛋白酶在许多细胞过程中发挥着至关重要的作用。这些酶活性的功能障碍与多种疾病的发病机制有关。影响基质金属蛋白酶及其抑制剂之间平衡相互作用的因素，如细胞外基质成分的基因突变或基质金属蛋白酶表达的失调，可导致各种疾病。由于它们在细胞外基质重塑中的重要作用，基质金属蛋白酶已成为作为与细胞外基质改变相关疾病诊断和预后生物标志物的研究热点。
Zotero 插件