Lampe L, Levashina E A
Vector Biology Unit, Max Planck Institute for Infection Biology, Berlin, Germany.
Parasite Immunol. 2017 Feb;39(2). doi: 10.1111/pim.12405.
In the last years, microRNAs (miRNAs) have been established as important post-transcriptional regulators of critical physiological processes in animals and plants. Here, we summarize what is known about miRNA biosynthesis, expression and function in the malaria vector mosquito Anopheles gambiae with a particular emphasis on the mosquito-parasite interactions. We discuss the important gaps in the current knowledge, including the potential of miRNA manipulation for future vector control strategies.
在过去几年中,微小RNA(miRNA)已被确认为动植物关键生理过程中重要的转录后调节因子。在此,我们总结了关于冈比亚按蚊这一疟疾传播媒介中miRNA生物合成、表达和功能的已知信息,特别强调了蚊虫与寄生虫之间的相互作用。我们讨论了当前知识中存在的重要空白,包括miRNA操纵在未来病媒控制策略中的潜力。