Hilgers G, Abrahams P J, Schouten R, Cornelis J J, Lehmann A R, Van der Eb A J, Rommelaere J
MRC Cell Mutation Unit, University of Sussex, Falmer, Brighton, United Kingdom.
C R Seances Soc Biol Fil. 1987;181(4):432-8.
Herpes Simplex Virus (HSV-1) was used to probe the expression of enhanced reactivation (ER) in cells from patients with ataxia telangiectasia (AT). The survival of UV-irradiated HSV-1 was increased as a result of UV- or X-preirradiation of both AT and normal cells. This result contrasts with our previous observation showing that contrary to normal cells AT cells are deficient for ER of a single-stranded DNA parvovirus. A difference between the molecular processes underlying ER of single- and double-stranded DNA viruses might explain these results.
单纯疱疹病毒1型（HSV-1）被用于探究共济失调毛细血管扩张症（AT）患者细胞中增强再激活（ER）的表达。紫外线或X射线预照射AT细胞和正常细胞后，紫外线照射的HSV-1的存活率增加。这一结果与我们之前的观察结果形成对比，之前的观察表明，与正常细胞相反，AT细胞缺乏单链DNA细小病毒的ER。单链和双链DNA病毒ER背后的分子过程差异可能解释了这些结果。
