[共济失调毛细血管扩张症和亨廷顿舞蹈症患者细胞中γ射线照射的细小病毒H-1的再激活]
[Reactivation of gamma-ray irradiated parvovirus H-1 in cells of patients with ataxia telangiectasia and Huntington's chorea].
作者信息
Hilgers G, Deleys-Hertoghs J, Cornelis J, Klein B, Rommelaere J
出版信息
C R Seances Soc Biol Fil. 1985;179(2):283-9.
PMID:2990639
Abstract
Parvovirus H-1 was used to probe the cellular radiosensitivity of two human degeneration syndromes AT and HC. No difference in the survival of gamma irradiated H-1 was detected between skin fibroblasts from such patients and from a normal individual. However, AT and normal cells were distinguished by the fact that the reactivation of irradiated H-1 could be increased by UV or X-irradiation of the latter but not of the former cells.
摘要
细小病毒H-1被用于探究两种人类退行性综合征——共济失调毛细血管扩张症（AT）和遗传性慢性粒细胞减少症（HC）的细胞放射敏感性。在这些患者的皮肤成纤维细胞与正常个体的皮肤成纤维细胞之间，未检测到经γ射线照射的H-1存活情况存在差异。然而，AT细胞与正常细胞的区别在于，紫外线或X射线照射后者可增加受照射H-1的再激活，而照射前者细胞则不会。
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