Schnitzer B, Roth M S, Hyder D M, Ginsburg D
Department of Pathology, University of Michigan Medical Center, Ann Arbor.
Cancer. 1988 Mar 15;61(6):1213-21. doi: 10.1002/1097-0142(19880315)61:6<1213::aid-cncr2820610626>3.0.co;2-c.
Three male children, ages 8, 11, and 14 at presentation, with the recently described Ki-1 lymphomas are reported. All three had lymph node involvement. The lymphoma was classified as immunoblastic in two children, and mixed small and large cell in the third child. In histologic terms, sinusoid, paracortical, and diffuse lymph node involvement by lymphoma was evident in each case. Both cases of immunoblastic lymphoma were T11+, T10+, T9+, HLA/Dr+, Tac+, Ki-1+, LCA+, and EMA+, while the lage neoplastic cells of the other case were T11+, Ki-1+, and LCA+. In all three cases DNA analysis of immunoglobulin heavy and light chain genes as well as T-cell receptor beta- and gamma-chain genes showed only germline patterns. The patients were treated with multi-agent chemotherapy. Two are in complete remission at 13 and 16 months, while the third failed to achieve remission and is alive with disease 12 months after a diagnosis had been established.
报告了3名男性儿童，就诊时年龄分别为8岁、11岁和14岁，患有最近描述的Ki-1淋巴瘤。3例均有淋巴结受累。其中2例淋巴瘤分类为免疫母细胞型，第3例为混合小细胞和大细胞型。从组织学角度看，每例均可见淋巴瘤呈窦状、副皮质区及弥漫性淋巴结受累。2例免疫母细胞型淋巴瘤均为T11+、T10+、T9+、HLA/Dr+、Tac+、Ki-1+、LCA+及EMA+，而另1例的大肿瘤细胞为T11+、Ki-1+及LCA+。3例免疫球蛋白重链和轻链基因以及T细胞受体β链和γ链基因的DNA分析均仅显示种系模式。患者接受了多药化疗。2例分别在13个月和16个月时完全缓解，而第3例未获缓解，确诊12个月后仍带瘤存活。
