Audouin J, Le Tourneau A, Diebold J, Reynes M, Tabbah I, Bernadou A
Service central Jacques Delarue d'Anatomie et de Cytologie Pathologiques, Hôtel-Dieu 1, Paris, France.
Hematol Oncol. 1989 Nov-Dec;7(6):441-9. doi: 10.1002/hon.2900070607.
A laparotomy performed for an occlusive syndrome, disclosed the presence of an ileal lymphoma in a renal graft recipient, 17 years after a first renal transplant. Mesenteric lymph node and spleen involvement were associated. The morphology of the large cells, the type of infiltration of the lymph node simulating metastatic carcinoma or malignant histiocytosis were highly suggestive of a new type of high grade malignancy lymphoma recently described which is called 'large cell anaplastic ML'. The immunolabelling study confirmed this diagnosis, demonstrating the following phenotype CD4, CD25 (TAC), CD30 (Ki-1), OKT 9 (transferrin receptor), EMA and HLA DR positivity. The tumour cells were negative for the other T, B and histiomonocytic markers. This case, of a large cell anaplastic Ki-1 positive lymphoma, expressing CD4, in a renal graft recipient shows that high grade ML in such patients are not all of the B cell type.
为治疗闭塞综合征而进行的剖腹手术显示，一名首次肾移植17年后的肾移植受者患有回肠淋巴瘤。肠系膜淋巴结和脾脏也受到累及。大细胞的形态、淋巴结浸润类型类似转移性癌或恶性组织细胞增多症，高度提示一种最近描述的新型高级别恶性淋巴瘤，即“大细胞间变性ML”。免疫标记研究证实了这一诊断，显示出以下表型：CD4、CD25（TAC）、CD30（Ki-1）、OKT 9（转铁蛋白受体）、EMA和HLA DR呈阳性。肿瘤细胞对其他T、B和组织细胞单核细胞标记物呈阴性。该例肾移植受者发生的大细胞间变性Ki-1阳性淋巴瘤表达CD4，表明此类患者中的高级别ML并非都是B细胞型。
