Yagihashi S, Sato I, Kaimori M, Matsumoto J, Nagai K
Department of Pathology, Hirosaki University School of Medicine, Japan.
Cancer. 1988 Mar 15;61(6):1241-7. doi: 10.1002/1097-0142(19880315)61:6<1241::aid-cncr2820610631>3.0.co;2-t.
Two cases of large cystic tumor of the pancreas in two young women are reported. Gross features and conventional light microscopic appearances of these tumors were consistent with those described as being the so-called papillary and cystic tumor (PCT) or solid and cystic tumor. Immunohistochemical staining for neuron-specific enolase was positive diffusely in both cases. Special stainings with Grimelius' silver impregnation, and stainings for insulin, glucagon, and somatostatin also were positive, although the population of positive cells was different in each case. Ultrastructural examinations confirmed the presence of numerous granules, probably neurosecretory, within the cytoplasm of many tumor cells in each case. Therefore, current cases were indistinguishable pathologically from the cystic nonfunctioning islet cell tumor. This study suggests that some PCT of the pancreas consist of endocrine cells predominantly.
报告了两名年轻女性胰腺大囊性肿瘤的病例。这些肿瘤的大体特征和传统光学显微镜表现与所谓的乳头状和囊性肿瘤（PCT）或实性和囊性肿瘤的描述一致。两例病例中神经元特异性烯醇化酶的免疫组化染色均呈弥漫性阳性。用格里梅利乌斯银浸染法进行的特殊染色以及胰岛素、胰高血糖素和生长抑素的染色也呈阳性，尽管每种情况下阳性细胞的数量不同。超微结构检查证实，在每例病例的许多肿瘤细胞胞质内均存在大量可能为神经分泌性的颗粒。因此，目前的病例在病理上与囊性无功能胰岛细胞瘤无法区分。本研究提示，胰腺的一些PCT主要由内分泌细胞组成。
